Results 71 to 80 of about 75,070 (261)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

A New Algorithm for Skin Lesion Border Detection in Dermoscopy Images

Journal of Biomedical Physics and Engineering, 2018
Background: With advances in medical imaging systems, digital dermoscopy has become one of the major imaging modalities in the analysis of skin lesions.
Meskini E., Helfroush M. S., Kazemi K., Sepaskhah M.   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

NSCT BASED LOCAL ENHANCEMENT FOR ACTIVE CONTOUR BASED IMAGE SEGMENTATION APPLICATION [PDF]

ICTACT Journal on Image and Video Processing, 2010
Because of cross-disciplinary nature, Active Contour modeling techniques have been utilized extensively for the image segmentation. In traditional active contour based segmentation techniques based on level set methods, the energy functions are defined ...
Hiren Mewada, Suprava Patnaik
doaj  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Digital Rebirth of Dongba Pattern: An Improved Active Contour Model for Pattern Contour Extraction

IEEE Access
In response to the time-consuming and laborious problem of manually drawing elements in existing poster designs, this paper proposes a method for extracting the contours of Dongba patterns based on improved active contour model.
Yuan Li, Tao Wu, Rongbing Fu, En Lu
doaj   +1 more source

Robust Evolution Method of Active Contour Models and Application in Segmentation of Image Sequence

Journal of Electrical and Computer Engineering, 2018
Active contour models are widely used in image segmentation. In order to obtain ideal object boundary, researchers utilize various information to define new models for image segmentation. However, the models could not meet all scenes of image.
Guoqi Liu, Haifeng Li
doaj   +1 more source

Detection and Segmentation of Retinal Lesions in Retcam 3 Images Based on Active Contours Driven by Statistical Local Features

Advances in Electrical and Electronic Engineering, 2019
Clinical retinal image analysis is an import aspect of clinical diagnosis in ophthalmology. Retinopathy of Prematurity (ROP) represents one of the most severe retinal disorders in prematurely born infants. One of the ROP clinical signs is the presence of
Jan Kubicek, Juraj Timkovic, Marek Penhaker, David Oczka, Veronika Kovarova, Alice Krestanova, Martin Augustynek, Martin Cerny   +7 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source