Results 111 to 120 of about 44,169 (308)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Active contour models in medical image segmentation

, 2000
Active contour models are very suitable to image segmentation. A contour is a set of point which has an energy function. This energy function comes from both internal and external sources. This paper includes internal and external energy definition and a
Nagy, Ivan
core  

A Charged Active Contour based on Electrostatics

, 2006
We propose a novel active contour model by incorporating particle based electrostatic interactions into the geometric active contour framework. The proposed active contour, embedded in level sets, propagates under the joint influence of a boundary ...
Yang, R, Xianghua Xie, Mirmehdi, M, Majid Mirmehdi, Ronghua Yang, Xianghua, Xie   +5 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A DSP-BASED active contour model

, 2004
In this paper a DSP-based active contour model for tracking of the endocardium in a sequence of echocardiographic images is presented. If a contour is available in the first frame of a sequence, the contours in the subsequent frames are segmented. Deformable active contours is a technique that combine geometry, physics and approximation theory in order
Zapata Pérez, Juan Francisco, Ruiz Merino, Ramón Jesús   +1 more
openaire   +1 more source

Predicting Tongue Shapes from a Few Landmark Locations [PDF]

, 2008
We present a method for predicting the midsagittal tongue contour from the locations of a few landmarks (metal pellets) on the tongue surface, as used in articulatory databases such as MOCHA and the Wisconsin XRDB.
Renals, S., Richmond, Korin, Wrench, Alan A., Renals, Steve, Qin, Chao, Carreira-Perpinan, Miguel A, Carreira-Perpiñán, M., Carreira-Perpinan, Miguel A., Richmond, K.; id_orcid, Wrench, A., Wrench, Alan A, Qin, C., Wrench, Alan   +12 more
core  

Automatic MRI Brain Tumor Segmentation System Based on Localizing Active Contour Models

, 2011
Conference Name:International Conference on Information Science, Automation and Material System. Conference Address: Zhengzhou, PEOPLES R CHINA. Time:MAY 21-22, 2011.In this paper, an automatic segmentation system was developed for MRI brain tumor. Local
Mao Qing Li, Zhi Xian Lin, Wang, Ying, Ying Wang, 李茂青, Cao, Jianguo, Jian Guo Cao, Lin, Zhixian, Li, Maoqing   +8 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source