Results 101 to 110 of about 2,113,682 (278)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Investigate on a Simplified Multi-Port Interline DC Power Flow Controller and Its Control Strategy

open access: yesEnergies, 2019
A DC power flow controller (DCPFC) can help to facilitate power flow routing in the multi-terminal high-voltage direct current (HVDC) transmission system.
Wen Wu   +3 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Impact of the Converter Control Strategies on the Drive Train of Wind Turbine during Voltage Dips

open access: yesEnergies, 2015
The impact of converter control strategies on the drive train of wind turbines during voltage dips is investigated in this paper using a full electromechanical model.
Fenglin Miao   +2 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

open access: yesMolecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir   +2 more
wiley   +1 more source

Modeling of a Pouch Lithium Ion Battery Using a Distributed Parameter Equivalent Circuit for Internal Non-Uniformity Analysis

open access: yesEnergies, 2016
A battery model that has the capability of analyzing the internal non-uniformity of local state variables, including the state of charge (SOC), temperature and current density, is proposed in this paper.
Dafen Chen   +4 more
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

Charging Guidance of Electric Taxis Based on Adaptive Particle Swarm Optimization

open access: yesThe Scientific World Journal, 2015
Electric taxis are playing an important role in the application of electric vehicles. The actual operational data of electric taxis in Shenzhen, China, is analyzed, and, in allusion to the unbalanced time availability of the charging station equipment ...
Liyong Niu, Di Zhang
doaj   +1 more source

The Flow Fingerprinting Game

open access: yes, 2013
Linking two network flows that have the same source is essential in intrusion detection or in tracing anonymous connections. To improve the performance of this process, the flow can be modified (fingerprinted) to make it more distinguishable. However, an
Elices, Juan A.   +1 more
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

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