Results 91 to 100 of about 12,914,546 (287)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Residential Demand Response Strategies and Applications in Active Distribution Network Management

, 2020
Electricity distribution is moving towards active, more flexible, smarter and decentralized energy systems. This transition requires System Operators (SO) to dynamically monitor and control the power flow across the network.
Sima Davarzani, I. Pisica, G. Taylor, K. Munisami   +3 more
semanticscholar   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A Novel Feature Engineering-Based SOH Estimation Method for Lithium-Ion Battery with Downgraded Laboratory Data

Batteries
Accurate estimation of lithium-ion battery state of health (SOH) can effectively improve the operational safety of electric vehicles and optimize the battery operation strategy.
Jinyu Wang, Caiping Zhang, Xiangfeng Meng, Linjing Zhang, Xu Li, Weige Zhang   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A Novel Data-Driven Fast Capacity Estimation of Spent Electric Vehicle Lithium-ion Batteries

Energies, 2014
Fast capacity estimation is a key enabling technique for second-life of lithium-ion batteries due to the hard work involved in determining the capacity of a large number of used electric vehicle (EV) batteries.
Caiping Zhang, Jiuchun Jiang, Weige Zhang, Yukun Wang, Suleiman M. Sharkh, Rui Xiong   +5 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Evaluation of Lithium-Ion Battery Thermal Runaway Initiation and Propagation: A Cross-Standard, Multilevel Evidence-Chain and Equivalence-Assessment Framework

Batteries
Thermal runaway (TR) initiation and propagation tests are essential for evaluating the safety of lithium-ion batteries (LIBs). However, differences among existing standards in application scenarios, test levels, initiation methods, boundary conditions ...
Xingzhen Zhou, Chenhui Gao, Qinhe Huang, Weige Zhang, Jinhan Qiu, Haohan Zhang   +5 more
doaj   +1 more source

Modeling of a Pouch Lithium Ion Battery Using a Distributed Parameter Equivalent Circuit for Internal Non-Uniformity Analysis

Energies, 2016
A battery model that has the capability of analyzing the internal non-uniformity of local state variables, including the state of charge (SOC), temperature and current density, is proposed in this paper.
Dafen Chen, Jiuchun Jiang, Xue Li, Zhanguo Wang, Weige Zhang   +4 more
doaj   +1 more source

33-node active distribution network.

, 2021
33-node active distribution network.
Yong Zheng (420246), Feng Zheng (91182), Weigang Huang (836624), Linfeng Zeng (11559366), Li Zhang (8200), Peng Kang (707736)   +5 more
core   +1 more source