Results 41 to 50 of about 6,760,865 (281)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Analysis of Earth Pressure Variation for Partial Displacement of Retaining Wall

Applied Sciences, 2021
Parts of the retaining wall might produce displacement under different load conditions. The moveable wall could impact the adjacent fixed wall, mainly reflecting on the variation of earth pressure and formation of the soil arching effect.
Hongbo Zhang, Mingpeng Liu, Pengfei Zhou, Zhizhong Zhao, Xiaoliang Li, Xiaobin Xu, Xiuguang Song   +6 more
doaj   +1 more source

Relationship between earth pressure and wall displacement based on Coulomb earth pressure model

Yantu gongcheng xuebao, 2018
The magnitude of earth pressure is greatly influenced by wall displacement. Based on the viewpoint that the relationship between wall displacement and lateral earth pressure is the macroscopic embodiment of soil stress-strain behavior, the relationship ...
XIE Tao 1,2, LUO Qiang 1,2, ZHANG Liang 1,2, JIANG Liang-wei 1,2, LIAN Ji-feng 1,2
doaj   +1 more source

Method to calculate active earth pressure considering soil arching effect under nonlimit state of clay

Yantu gongcheng xuebao, 2020
By taking the limited range of clay behind the retaining wall as the research object, considering soil arching effect under non-limit state, and adopting the angle of the fracture surface obtained by the plastic upper limit theory and the variation law ...
XU Ri-qing 1, 2, XU Ye-bin 1, 2, CHENG Kang 1, 2, FENG Su-yang 1, 2, SHEN Shuo 1, 2
doaj   +1 more source

Passive and active earth pressures in the presence of groundwater flow [PDF]

Géotechnique, 2006
This paper deals with the effect of seepage flow on the lateral earth pressures acting on deep sheeted excavations in cohesionless soil. The computation of the passive and active earth pressures in the presence of hydraulic gradients is performed using the explicit finite difference method implemented in Fast Lagrangian Analysis of Continua (FLAC ...
Benmebarek, N., Benmebarek, S., Kastner, Richard, Soubra, Abdul-Hamid   +3 more
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Earth Pressure Calculation Method for Deep Foundation Pit Excavation in Chengdu Pebble Stratum Area

Chengshi guidao jiaotong yanjiu
Objective The existing theoretical calculation method of earth pressure does not take into account the discrete characteristics of pebble stratum such as large porosity and loose structure, and the calculated results are different from the actual earth ...
LI Shu, YAN Sheng, ZHANG Xiao, YANG Henghong   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Dynamic Active Earth Pressures of the Retaining Piles with Anchors under Vehicle Loads

Shock and Vibration, 2016
The pile-anchor supporting structure is widely used in foundation pit engineering; then knowledge of active earth pressure on piles is very important for engineers.
Hong-zhi Qiu, Ji-ming Kong, Ren-chao Wang   +2 more
doaj   +1 more source