Results 71 to 80 of about 6,760,865 (281)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

ResearchontheEarthPressureDistributionBehindthe RetainingWall UnderSeismic AccelerationInfluence

工程科学与技术, 2015
:Assuming the variation of the seismic coefficient with height and by using the pseudo-dynamic method, the thin-layer micro-element method and limit equilibrium principles,a new formulation was proposed to calculate the active seismic pressure on ...
何思明, 王忠福, 王娟
doaj  

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Force Polygon and Seismic Active Earth Pressure on the Back of a Retaining Wall Supporting c-F Backfill

, 2011
The study presents a rational graphical approach to discover the dynamic active earth pressure on the back of a battered face retaining wall having inclined c-F backfill with surcharge load over the top of backfill. Considering the seismic forces as time
Richi Prasad Sharma, Sima Ghosh
core   +1 more source

Calculation of earth pressure on rigid retaining wall based on model indeterminacy

Yantu gongcheng xuebao, 2017
The earth pressure on rigid retaining wall considering model indeterminacy is focused. Based on the force equilibrium equations for sliding mass, the functional extreme-value isoperimetric model for earth pressure in the general case is derived ...
CHEN Jian-gong 1, 2, ZHANG Hai-quan 1, 2, XU Ming 3, ZHAO Xin-yao 1, 2, YANG Ze-jun 1, 2
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Active and Passive Earth Pressure Calculation Method for Double-Row Piles considering the Nonlinear Pile Deformation

, 2022
The double-row pile supporting structure has been widely used in foundation pit excavations. When analyzing the effect of earth pressure on the pile structure, previous research only considered the double-row piles as the rigid body and the pile-soil ...
Yulong Chen, Yijun Zhou
core   +1 more source

Nonlinear calculation of earth pressures considering displacement effect

Yantu gongcheng xuebao, 2019
There is much difference between the calculated results of ultimate earth pressure theory and the experimental ones. To solve this problem, based on the Rankine's earth pressure theory and the two-parameter method, an earth pressure method considering ...
WANG Zheng-zhen 1, 2, GONG Wei-ming 1, 2, DAI Guo-liang 1, 2, LIU Xiao-guang 3, ZHAO Xin-xin 3, GUO Hui 3
doaj   +1 more source