Results 81 to 90 of about 893,458 (334)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Stability Assessment of Earth Retaining Structures under Static and Seismic Conditions

Infrastructures, 2019
An accurate estimation of static and seismic earth pressures is extremely important in geotechnical design. The conventional Coulomb’s approach and Mononobe-Okabe’s approach have been widely used in engineering practice.
Sanjay Nimbalkar, Anindya Pain, Syed Mohd Ahmad, Qingsheng Chen   +3 more
doaj   +1 more source

Neutral and Cationic Rare Earth Metal Alkyl and Benzyl Compounds with the 1,4,6-Trimethyl-6-pyrrolidin-1-yl-1,4-diazepane Ligand and Their Performance in the Catalytic Hydroamination/Cyclization of Aminoalkenes [PDF]

, 2008
A new neutral tridentate 1,4,6-trimethyl-6-pyrrolidin-1-yl-1,4-diazepane (L) was prepared. Reacting L with trialkyls M(CH2SiMe3)3(THF)2 (M = Sc, Y) and tribenzyls M(CH2Ph)3(THF)3 (M = Sc, La) yielded trialkyl complexes (L)M(CH2SiMe3)3 (M = Sc, 1; M = Y ...
Arndt S., Arndt S., Bambirra S., Bambirra S., Bambirra S., Bambirra S., Bambirra S., Bambirra S., Bambirra S., Bambirra S., Booij M., Carver C. T., De Kimpe N., Douglass M. R., Douglass M. R., Evans W. J., Gagné M. R., Gagné M. R., Gao W., Ge S, Ge S., Ge S., Ge S., Giardello M. A., Gribkov D. V., Hajela S., Hayes P. G., Hong S, Horino Y., Howe R. G., Kawaoka A. M., Kim J. Y., Komeyama K., Lappert M. F., Lauterwasser F., Lawrence S. C., Li W., Liu Y., Lukesova L., Lukesova L., Meyer N., Meyer N., Molander G. A., Molander G. A., Nishiura M., Robert D., Ryu J. -S, Sakakura Y., Shannon R. D., Stubbert B. D., Tardif O., Tazelaar C. G. J., Tokuda M., Tredget C. S., Trifonov A. A, Wang Q., Ward B. D., Yu P. F., Yuen H. F., Zeimentz P. M., Zhang L.   +60 more
core   +3 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Synthesis of Alkaline Earth Diazenides MAEN2 (MAE = Ca, Sr, Ba) by Controlled Thermal Decomposition of Azides under High Pressure [PDF]

, 2012
The alkaline earth diazenides MAEN2 with MAE = Ca, Sr and Ba were synthesized by a novel synthetic approach, namely, a controlled decomposition of the corresponding azides in a multianvil press at highpressure/ high-temperature conditions.
Andersen O. K., Auffermann G., Auffermann G., Auffermann G., Auffermann G., Bergmann J., Chen W., Chen Z. W., Chhowalla M., Coelho A. A., Crowhurst J. C., Crowhurst J. C., Dronskowski R., Du X. P., Ehrlich P., Fair H. D., Frierson W. J., Gregoryanz E., Huppertz H., Jepsen O., Jhi S. H., Kawai N., Lambrecht W. R. L., Leineweber A., Maruyama T., McMillan P. F., Montoya J. A., Prots Y., Rainer Frankovsky, Remy-Gennete P., Rubie D. C., Römer S. R., Sebastian B. Schneider, Skriver H. L., Vajenine G. V., von Appen J., Walker D., Walker D., Wang H., Weidlein J., Wessel M., Wessel M., Wessel M., Wolfgang Schnick, Wu Z. G., Yamanaka S., Young A. F., Yu R., Zerr A.   +48 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Stellar Coronal and Wind Models: Impact on Exoplanets

, 2017
Surface magnetism is believed to be the main driver of coronal heating and stellar wind acceleration. Coronae are believed to be formed by plasma confined in closed magnetic coronal loops of the stars, with winds mainly originating in open magnetic field
A Maggio, A Morgenthaler, A Morgenthaler, A Reiners, A Reiners, A Reiners, A Strugarek, A Telleschi, A. Skumanich, AA Pevtsov, AA Vidotto, AA Vidotto, AA Vidotto, AA Vidotto, AA Vidotto, AA Vidotto, AA Vidotto, AA Vidotto, AA Vidotto, AA Vidotto, AA Vidotto, AA Vidotto, AA Vidotto, AA Vidotto, AA Vidotto, AA Vidotto, AA West, AF Lanza, B Holst van der, B Holst van der, B Zieger, BA Nicholson, BE Wood, BE Wood, BE Wood, BE Wood, BE Wood, BJ Wargelin, BO Demory, C Catala, C Garraffo, C Johnstone, C. P. Johnstone, CM Johns-Krull, CM Johns-Krull, CP Folsom, CP Johnstone, CP Johnstone, D Arzoumanian, D Bisikalo, D Buzasi, D Falceta-Gonçalves, D Lai, E Shkolnik, EF Guinan, EJ Gaidos, F Bagenal, G Anglada-Escudé, G Scandariato, GAJ Hussain, GAJ Hussain, GAJ Hussain, GHJ Oord van den, GW Pneuman, H Lammer, H Lammer, H Washimi, I Baraffe, I Pillitteri, I Ribas, I. Ribas, IA Waite, IA Waite, IA Waite, Ignasi Ribas, IV Sokolov, J Donati, J Donati, J Donati, J Donati, J Llama, J Morin, J Morin, J Morin, J Morin, J Sanz-Forcada, J Zendejas, Jackie Villadsen, JD Alvarado-Gómez, Jeremy Lim, JF Donati, JF Donati, JF Donati, JF Donati, JF Donati, JF Donati, JF Donati, JF Donati, JF Donati, JF Donati, JH Debes, JI Zuluaga, JJG Lima, JM Grießmeier, JM Grießmeier, JV Hollweg, K Tsinganos, KG Kislyakova, L Hartmann, L. Mestel, M Guedel, M Guedel, M Güdel, M Jardine, M Jardine, MG Sterenborg, ML Khodachenko, ML Khodachenko, N Pizzolato, NJ Wright, O Cohen, O Cohen, O. Cohen, O. Cohen, P Lang, P Petit, P Petit, P Testa, R Fares, R Fares, R Fares, R Fares, R Keppens, R Pallavicini, RD Jeffries, Robert P. Kraft, Rui F. Pinto, RVE Lovelace, S Boro Saikia, S Boro Saikia, S Matt, S. V. Jeffers, SC Marsden, SC Marsden, SG Parsons, SH Yang, SK Solanki, SL Li, SP Matt, SR Cranmer, SR Cranmer, T Matsakos, T Matsumoto, Takuma Matsumoto, TE Holzer, Theresa Lüftinger, TK Suzuki, V Jatenco-Pereira, V Réville, V See, V. Bourrier, V. Bourrier, WH Ip   +162 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source