Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Fault tectonics and earthquake hazards in parts of southern California [PDF]
The author has identified the following significant results. Four previously unknown faults were discovered in basement terrane of the Peninsular Ranges.
Gazley, C., Jr. +4 more
core +1 more source
An improved glimpse into earthquake activity in northeastern Alaska [PDF]
, 2018 The northeastern Brooks Range is long known to be seismically active, but meaningful analysis of the earthquake activity has been limited by the lack of instrumentation.
Buurman, Helena
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Corrigendum: New insights into the paleoseismic history of the Mae Hong Son Fault, Northern Thailand
Frontiers in Earth Science, 2023 Chanista Chansom +7 more
doaj +1 more source
Earthquake and Seismogenic Fault, and What is the Active Fault
, 2013 Haruo Yamazaki
openalex +2 more sources
A Comprehensive Method for Fault Location of Active Distribution Network Based on Improved Matrix Algorithm and Optimization Algorithm [PDF]
, 2022 Zhen Li +3 more
openalex +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Active Fault Determination Methods in Urban Area, Case Study: Application of GPR Method on North Shahre Ray Fault, South of Tehran, Iran [PDF]
, 2011 Ahmad Khorsandi Aghai +2 more
openalex +1 more source