Results 151 to 160 of about 59,307 (309)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
To address issues such as inadequate fault tolerance, long computation time, and limited universality in fault location for active distribution networks, this paper proposes a fault location method that combines Petri nets with an improved particle swarm
Jie Yang +4 more
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Using integrated geophysics data set to delineate Phetchabun active fault in Thailand. [PDF]
Data Brief, 2020 Arjwech R +4 more
europepmc +1 more source
Microstructural and geochemical processes in long-lived reactivated crustal-scale fault zones: A case study from the Median Tectonic Line, SW Japan. [PDF]
, 2006 The Median Tectonic Line (MTL) is a major, crustal-scale fault in Japan that separates the low-P/high-T Ryoke metamorphic belt of mainly subduction related granitoids from the high-P/low-T Sambagawa Belt of accretionary complex metasedimentary rocks ...
Sharon P. Jefferies, +1 more
core
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Structural analysis extended with active fault isolation - methods and algorithms
, 2009 Isolability of faults is a key issue in fault diagnosis whether the aim is maintenance or active fault-tolerant control. It is often encountered that while faults are detectable, they are only group-wise isolable from a usual diagnostic point of view ...
Blanke, Mogens, Gelso, Esteban,
core
Characterisation of the 2D and 3D density and connectivity attributes of fracture systems in carbonate reservoir analogues: implications for fluid flow [PDF]
, 2013 Fault zones, hosted in fractured carbonate reservoirs, can behave as either high porosity and permeability conduits, favoring the migration of fluids; or, conversely, as low porosity and permeability barriers, retarding fluid flow, due to the presence of
Sagi, David Adam, SAGI, DAVID,ADAM
core
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source