Results 131 to 140 of about 59,307 (309)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Using reflection seismic technology to detect urban active faults in Guanzhong area
地球与行星物理论评The neotectonic movement is active in Guanzhong Basin, with extensive development of ground fissures and active faults. To solve the problem of uncertain distribution of concealed active faults in urban areas, in this study, active fault detection was ...
Guangcai Li +5 more
doaj +1 more source
, 2015 This paper presents a neural network method to locate common fault exactly in a distribution power system (DPS) with renewable sources. The back propagation (BP) neural network method is applied to identify patterns of voltage and current measured from ...
Li XH(李先宏) +10 more
core +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Dynamic Stability Analysis of Subsea Tunnel Crossing Active Fault Zone: A Case Study
Journal of Marine Science and EngineeringThe rock strength in an active fault zone is low and the surrounding rock is fractured and has poor stability, making any subsea tunnel crossing the active fault zone extremely susceptible to disasters such as tunnel collapse, sudden water ingress, and ...
Zhiqiang Li +7 more
doaj +1 more source
Fracture characteristics from two reactivated basement fault zones: examples from Norway and Shetland [PDF]
, 2001 Detailed analyses of fracture attributes developed in basement rocks associated with two, crustal-scale faults, have enabled the characteristics and evolution of the fracture system geometry to be documented quantitatively.
Sleight, Janine Michelle
core
, 2012 This is the post-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2012 IEEE.This paper addresses the fault detection problem for discrete-time Markovian jump systems with incomplete knowledge ...
Wang, Z, Gao, H, Dong, H
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Remote SensingThe spatial variability of input parameters plays a crucial role in the interpretation of geomorphic indices, with digital elevation models (DEMs) being the primary data source.
Hyunjee Lim +4 more
doaj +1 more source