Results 131 to 140 of about 3,734,613 (296)

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Influence of Digital Elevation Model Resolution on the Normalized Stream Length–Gradient Index in Intraplate Regions: A Case Study of the Yangsan Fault, Korea

Remote Sensing
The spatial variability of input parameters plays a crucial role in the interpretation of geomorphic indices, with digital elevation models (DEMs) being the primary data source.
Hyunjee Lim, Sangmin Ha, Sohee Kim, Hee-Cheol Kang, Moon Son   +4 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

The strong earthquakes and seismogenic structures in eastern margin of Tibetan Plateau and adjacent areas: A preface for the special topic

地震科学进展
The eastern margin of the Tibetan Plateau is composed of multiple secondary tectonic units which constitute typical “multi-level extrusion-rotation active tectonic system”.
Zhonghai Wu, Zhongtai He, Ning Zhong, Jingxing Yu, Bo Zhang   +4 more
doaj   +1 more source

A Fault Location Method for Active Distribution Network with Renewable Sources Based on BP Neural Network

, 2015
This paper presents a neural network method to locate common fault exactly in a distribution power system (DPS) with renewable sources. The back propagation (BP) neural network method is applied to identify patterns of voltage and current measured from ...
Li XH(李先宏), Zhang Tong, Yu HB(于海斌), Zeng Peng, Sun Lanxiang, Zhang T(张彤), Sun LX(孙兰香), Zeng P(曾鹏), Yu Haibin, Liu JC(刘建昌), Liu Jianchang   +10 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Absolute Dating of Fault-Gouge Material Using Isothermal Thermoluminescence: An Example from the Nojima Fault Zone, SW Japan

Geosciences
Establishing the absolute age of palaeoearthquakes is of great significance for the assessment of the seismicity and seismic hazards of a region. As such, several different geochronological techniques to date earthquake-related material have been ...
Evangelos Tsakalos, Eleni Filippaki, Aiming Lin, Maria Kazantzaki, Takafumi Nishiwaki, Yannis Bassiakos   +5 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Corrigendum: New insights into the paleoseismic history of the Mae Hong Son Fault, Northern Thailand

Frontiers in Earth Science, 2023
Chanista Chansom, Chanista Chansom, Sukonmeth Jitmahantakul, Sukonmeth Jitmahantakul, Lewis A. Owen, Weerachat Wiwegwin, Punya Charusiri, Punya Charusiri   +7 more
doaj   +1 more source