Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
A Novel Active Fault-Tolerant Tracking Control for Robot Manipulators with Finite-Time Stability. [PDF]
Sensors (Basel), 2021 Truong TN, Vo AT, Kang HJ, Van M.
europepmc +1 more source
Operational control and protection implications of fault current limitation in distribution networks
, 2009 Rising short-circuit fault current levels is one of the problems associated with the increased presence of distributed generation (DG) in electrical networks.
Blair, S.M. +3 more
core
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Nonlinear Predictive Motion Control for Autonomous Mobile Robots Considering Active Fault-Tolerant Control and Regenerative Braking. [PDF]
Sensors (Basel), 2022 Hang P, Lou B, Lv C.
europepmc +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Design of Active Fault-Tolerant Control System for Air-Fuel Ratio control of Internal Combustion engine using nonlinear regression-based observer model. [PDF]
PLoS One, 2022 Alsuwian T +5 more
europepmc +1 more source
Breaking up the hanging wall of a rift-border fault: The 2009 Karonga earthquakes, Malawi
The southern East African Rift has an unusually large seismogenic thickness (35–40 km), which is responsible for wide tilted basins and extremely long faults with the potential for M7-8 normal-faulting earthquakes.
Nissen, E. +4 more
core +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Active Fault Localization of Actuators on Torpedo-Shaped Autonomous Underwater Vehicles. [PDF]
Sensors (Basel), 2021 Liu F +5 more
europepmc +1 more source