Results 101 to 110 of about 3,734,613 (296)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Editorial: Understanding the marginal seas of northeast asia for tectonics and submarine geohazards

Frontiers in Earth Science, 2022
Kwang-Hee Kim, Han-Joon Kim, Tianyao Hao, Tianyao Hao, Tianyao Hao, Xunhua Zhang   +5 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Editorial note for the Geodesy and Geodynamics journal special issue: Remote Sensing and GIS applications in crustal deformation and neotectonics

Geodesy and Geodynamics, 2022
Ajay Kumar Taloor, Girish Chandra Kothyari, Shangmin Zhao, Rajwant, Mayank Joshi   +4 more
doaj   +1 more source

New research progress on the strong earthquakes and seismogenic structures in eastern margin of Tibetan Plateau and adjacent areas: A preface for the special topic

地震科学进展
The eastern margin of the Tibetan Plateau is a tectonic transformation belt regulating the eastward extrusion of materials from the plateau. This area not only has high density active faults and high frequency strong earthquakes, but also has very ...
Zhonghai Wu, Zhongtai He, Ning Zhong, Jingxing Yu, Bo Zhang   +4 more
doaj   +1 more source

A Novel Active Fault-Tolerant Tracking Control for Robot Manipulators with Finite-Time Stability. [PDF]

Sensors (Basel), 2021
Truong TN, Vo AT, Kang HJ, Van M.
europepmc   +1 more source

Localization of Quaternary slip rates in an active rift in 10(5) years: an example from central Greece constrained by U-234-Th-230 coral dates from uplifted paleoshorelines [PDF]

, 2009
Mapping, dating, and modeling of paleoshorelines uplifted in the footwall of the 1981 Gulf of Corinth earthquake fault, Greece (Ms 6.9–6.7), are used to assess its slip rate history relative to other normal faults in the area and study strain ...
Wigley, T., Cowie, P A, S. L. Houghton, J. M. McArthur, McArthur, J. M., Papanikolaou, I, Cooper, Frances J, T. Wigley, van Calsteren, Peter, C. Underwood, Underwood, Charlie J., Cowie, P.A., F. J. Cooper, Cooper, F.J., Roberts, Gerald P., van Calsteren, P, Houghton, S. L., McArthur, J.M., Papanikolaou, Ioannis D., Papanikolaou, I., Wigley, T, P. van Calsteren, Cowie, P. A., Houghton, S L, I. Papanikolaou, Roberts, G. P., Roberts, G P, McArthur, J M, Cooper, F. J., G. P. Roberts, P. A. Cowie, Underwood, C., Underwood, C, van Calsteren, P., Houghton, S.L.   +34 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Nonlinear Predictive Motion Control for Autonomous Mobile Robots Considering Active Fault-Tolerant Control and Regenerative Braking. [PDF]

Sensors (Basel), 2022
Hang P, Lou B, Lv C.
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source