Results 91 to 100 of about 3,734,613 (296)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

open access: yesFEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Geometry, evolution and scaling of fault relay zones in 3D using detailed observations from outcrops and 3D seismic data [PDF]

open access: yes, 2011
A new surface attribute was developed during the course of the thesis, which enables fault-related deformation – specifically, the apparent dip of mapped horizons measured in a direction perpendicular to the average strike of a fault array (here termed ...
Long, Jonathan James   +1 more
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Reaktivitas Sesar Kaligarang, Semarang

open access: yesIndonesian Journal on Geoscience, 2014
http://dx.doi.org/10.17014/ijog.vol3no3.20082Kaligarang Fault which cuts across Semarang City in a north-south direction has been activated for long periods.
S. Poedjoprajitno   +2 more
doaj   +1 more source

Reinforcement learned adversarial agent (ReLAA) for active fault detection and prediction in space habitats. [PDF]

open access: yesNPJ Microgravity, 2023
Overlin M   +4 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Geospatial technology applications in Quaternary Science

open access: yesQuaternary Science Advances, 2022
Ajay Kumar Taloor   +3 more
doaj   +1 more source

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