Results 121 to 130 of about 5,589,366 (302)

Influence of Digital Elevation Model Resolution on the Normalized Stream Length–Gradient Index in Intraplate Regions: A Case Study of the Yangsan Fault, Korea

Remote Sensing
The spatial variability of input parameters plays a crucial role in the interpretation of geomorphic indices, with digital elevation models (DEMs) being the primary data source.
Hyunjee Lim, Sangmin Ha, Sohee Kim, Hee-Cheol Kang, Moon Son   +4 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The strong earthquakes and seismogenic structures in eastern margin of Tibetan Plateau and adjacent areas: A preface for the special topic

地震科学进展
The eastern margin of the Tibetan Plateau is composed of multiple secondary tectonic units which constitute typical “multi-level extrusion-rotation active tectonic system”.
Zhonghai Wu, Zhongtai He, Ning Zhong, Jingxing Yu, Bo Zhang   +4 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Absolute Dating of Fault-Gouge Material Using Isothermal Thermoluminescence: An Example from the Nojima Fault Zone, SW Japan

Geosciences
Establishing the absolute age of palaeoearthquakes is of great significance for the assessment of the seismicity and seismic hazards of a region. As such, several different geochronological techniques to date earthquake-related material have been ...
Evangelos Tsakalos, Eleni Filippaki, Aiming Lin, Maria Kazantzaki, Takafumi Nishiwaki, Yannis Bassiakos   +5 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Definitions, Classification Schemes for Active Faults, and Their Application

Geosciences
Active faults are generally defined as faults that have moved in the past and will continue to be active in the future. They are expected to cause deformation and potential disasters if they are localized close to human activities.
Zhonghai Wu, Mengmeng Hu
doaj   +1 more source

Using integrated geophysics data set to delineate Phetchabun active fault in Thailand. [PDF]

Data Brief, 2020
Arjwech R, Boonsungnern W, Sriwangpon P, Somchat K, Pondthai P.   +4 more
europepmc   +1 more source

Bayesian Diagnosability and Active Fault Identification

2025 IEEE 64th Conference on Decision and Control (CDC)
We study fault identification in discrete-time nonlinear systems subject to additive Gaussian white noise. We introduce a Bayesian framework that explicitly accounts for unmodeled faults under reasonable assumptions. Our approach hinges on a new quantitative diagnosability definition, revealing when passive fault identification (FID) is fundamentally ...
Chun-Wei Kong, Jay W. McMahon, Morteza Lahijanian   +2 more
openaire   +2 more sources