Results 141 to 150 of about 59,307 (309)

Effect of active faults in the groundwater level of Shaharchay basin in Urmia [PDF]

تحقیقات کاربردی علوم جغرافیایی, 2017
حذف شدیک جمله Identify water resources management and proper application of relevant officials and managers are the main concern. Groundwater as a most important natural resources of Iran needs to planning and management of all aspects. In this regard, a
Tayebeh Kiani, Zahra Yousefi
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The strong earthquakes and seismogenic structures in eastern margin of Tibetan Plateau and adjacent areas: A preface for the special topic

地震科学进展
The eastern margin of the Tibetan Plateau is composed of multiple secondary tectonic units which constitute typical “multi-level extrusion-rotation active tectonic system”.
Zhonghai Wu, Zhongtai He, Ning Zhong, Jingxing Yu, Bo Zhang   +4 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Absolute Dating of Fault-Gouge Material Using Isothermal Thermoluminescence: An Example from the Nojima Fault Zone, SW Japan

Geosciences
Establishing the absolute age of palaeoearthquakes is of great significance for the assessment of the seismicity and seismic hazards of a region. As such, several different geochronological techniques to date earthquake-related material have been ...
Evangelos Tsakalos, Eleni Filippaki, Aiming Lin, Maria Kazantzaki, Takafumi Nishiwaki, Yannis Bassiakos   +5 more
doaj   +1 more source

A study on transient enhancement for fault diagnosis based on an active noise control system

Active noise control (ANC) is a more effective technique used for acoustic noise cancelation in comparison with passive approaches which are difficult and expensive to implement, especially for cancelling the noise in the low frequency range.
Gu, Fengshou, Ball, Andrew, Zhen, Dong, Tran, Van Tung, Tian, X.   +4 more
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Definitions, Classification Schemes for Active Faults, and Their Application

Geosciences
Active faults are generally defined as faults that have moved in the past and will continue to be active in the future. They are expected to cause deformation and potential disasters if they are localized close to human activities.
Zhonghai Wu, Mengmeng Hu
doaj   +1 more source

Bayesian Diagnosability and Active Fault Identification

2025 IEEE 64th Conference on Decision and Control (CDC)
We study fault identification in discrete-time nonlinear systems subject to additive Gaussian white noise. We introduce a Bayesian framework that explicitly accounts for unmodeled faults under reasonable assumptions. Our approach hinges on a new quantitative diagnosability definition, revealing when passive fault identification (FID) is fundamentally ...
Chun-Wei Kong, Jay W. McMahon, Morteza Lahijanian   +2 more
openaire   +2 more sources