Results 181 to 190 of about 676,585 (361)

Vascular endothelial‐cadherin as a marker of endothelial injury in preclinical Alzheimer disease

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1926-1940, December 2022., 2022
Abstract Objective Endothelial dysfunction is an early and prevalent pathology in Alzheimer disease (AD). We here investigate the value of vascular endothelial‐cadherin (VEC) as a cerebrospinal fluid (CSF) marker of endothelial injury in preclinical AD.
Rawan Tarawneh, Rachel S. Kasper, Jessie Sanford, Chia‐Ling Phuah, Jason Hassenstab, Carlos Cruchaga   +5 more
wiley   +1 more source

Map showing recently active breaks along the Green Valley fault, Napa and Solano counties, California [PDF]

, 1976
V.A. Frizzell, Richard D. Brown
openalex   +1 more source

Learning-Based Passive Fault-Tolerant Control of a Quadrotor with Rotor Failure [PDF]

arXiv
This paper proposes a learning-based passive fault-tolerant control (PFTC) method for quadrotor capable of handling arbitrary single-rotor failures, including conditions ranging from fault-free to complete rotor failure, without requiring any rotor fault information or controller switching.
arxiv  

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

FEBS Open Bio, EarlyView.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law, Yuan Gao, Sravya Kovvali, Pankajavalli Thirugnanasambantham, Vicki H. Wysocki, Brian M. M. Ahmer, Venkat Gopalan   +6 more
wiley   +1 more source

DC fault current clearance coordinated control strategy for DC grid with hybrid MMC

International Journal of Electrical Power & Energy Systems
For DC grid based on the hybrid modular multilevel converter (MMC), the traditional DC fault current clearance scheme takes a long time and greatly affects the active power transmission.
Shouqi Jiang, Tuo Wang, Guoqing Li, Yechun Xin, Lixin Wang   +4 more
doaj  

Coupled Boundary Element and Finite Volume Methods for Modeling Fluid-Induced Seismicity in Fault Networks within Low-Permeability Rocks [PDF]

arXiv
To better understand the mechanics of injection-induced seismicity, we developed a two-dimensional numerical code to simulate both seismic and aseismic slip on non-planar faults and fault networks driven by fluid diffusion along permeable faults. Our approach integrates a boundary element method to model fault slip governed by rate-and-state friction ...
arxiv  

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Mapping Hsp104 interactions using cross‐linking mass spectrometry

FEBS Open Bio, EarlyView.
This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal, Karolina Michalska, Andrzej Joachimiak, Lukasz A. Joachimiak   +3 more
wiley   +1 more source

Alkane biosynthesis gene expression and its increased production in recombinant cyanobacteria

FEBS Open Bio, EarlyView.
The transcription and mRNA structures of the alkane biosynthesis genes ado/aar were analysed in the representative cyanobacteria PCC 6803 and SK1‐2‐1, which produce C17H36 and C15H32, respectively. PCC 6803 transconjugants carrying these genes showed a 1.8‐ to 2.3‐fold increase in C17H36 production.
Misato Nagao, Takato Ozaki, Hirofumi Fukuda, Yu Kanesaki, Munehiko Asayama   +4 more
wiley   +1 more source

Newly Discovered NE-Striking Dextral Strike-Slip Holocene Active Caimashui Fault in the Central Part of the Sichuan-Yunnan Block and Its Tectonic Significance

Remote Sensing
The Sichuan-Yunnan block is a tectonically active region in China, with frequent large earthquakes occurring in and around it. Despite most earthquakes being concentrated along boundary faults, intraplate faults also have the potential to generate ...
Xin Tan, Kuan Liang, Baoqi Ma, Zhongtai He   +3 more
doaj   +1 more source