Results 91 to 100 of about 4,238,869 (290)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

An Improved Adaptive Harmonic Current Detection Algorithm in Active Filter

Kongzhi Yu Xinxi Jishu, 2017
It proposed an improved adaptive harmonic current detection algorithm for active filter based on the shortcoming of the existing variable step-size LMS algorithm for harmonic current detection.
TAN Xitang, WANG Mujiang, ZHU Qinyue, ZHANG Tianyu, ZHANG Youhua   +4 more
doaj  

Single EX-CCCII-Based First-Order Versatile Active Filter

Applied Sciences
This paper presents a new current-mode first-order versatile active filter employing one extra-x second-generation current controlled current conveyor (EX-CCCII) and one grounded capacitor.
Montree Kumngern, Fabian Khateb, Tomasz Kulej   +2 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

WAYS OF P-Q THEORY MODERNIZATION FOR WORK IN NON-SINUSOIDAL UNBALANCED VOLTAGE CONDITIONS

Electrical engineering & Electromechanics, 2013
Two different techniques of P-Q instantaneous power theory mathematical apparatus modernization for shunt active filters are analyzed. Both techniques are equal in nature while different in implementation.
V.S. Kozlov, V.A. Kolsun, A.F. Sinolitsyy   +2 more
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

FPAA-based implementation of fractional-order chaotic oscillators using first-order active filter blocks. [PDF]

J Adv Res, 2020
Silva-Juárez A, Tlelo-Cuautle E, de la Fraga LG, Li R.   +3 more
europepmc   +1 more source

Frequency Selective Control of a Parallel Active Filter with Resonance Filter Regulators

The paper describes a method for frequency selective control of parallel active filters that are applied for compensation of the current harmonic distortions and the displacement power factor in symmetrical three-phase systems with a known harmonic ...
Ribickis, Leonīds, Krievs, Oskars
core  

New hybrid parallel active filter configuration minimising active filter size

, 2019
The authors propose a new topology for a hybrid parallel active filter that can further reduce the active filter (inverter) power rating. The basic idea is to install the active filter in parallel with the passive filter inductor.
Sung, JH, Park, S, Nam, K
core   +1 more source

A study on transient enhancement for fault diagnosis based on an active noise control system [PDF]

Active noise control (ANC) is a more effective technique used for acoustic noise cancelation in comparison with passive approaches which are difficult and expensive to implement, especially for cancelling the noise in the low frequency range.
Gu, Fengshou, Ball, Andrew, Zhen, Dong, Tran, Van Tung, Tian, X.   +4 more
core   +3 more sources