ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Reliable and
IEEE Access, 2018 This paper presents three new floating active inductor (FAI)-based bandpass filter (BPF) topologies, namely, the nominal-Q BPF (NQF), Q-enhanced BPF-1 (QF1), and Q-enhanced BPF-2 (QF2). The filters utilize voltage differencing transconductance amplifier (
Rishab Mehra, Vikash Kumar, Aminul Islam
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Improving air filter efficiency as a strategy to reduce children’s exposure to traffic related air pollutants in energy-efficient classrooms [PDF]
, 2016 This study was organised to quantify the effect of upgrading the filter efficiency in balance ventilation systems on indoor exposure to traffic-related air pollution, in 4 primary school classrooms.
Constandt, Kim +7 more
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
IMITATION MODELING OF THE HYBRID VAR COMPENSATOR
Elektrotehnìka ta Elektroenergetika, 2019 Purpose. Study of the effectiveness of the hybrid VAR compensator, which consists of series-connected capacitor bank (CB) with discrete regulation and active filter of higher harmonics, with different control strategies, under asymmetrical and / or non ...
O.S. Savenko +2 more
doaj +1 more source
Simulation of a single-phase active power filter based ANN controller [PDF]
, 2013 This project presents the employment of a single-phase active power filter (APF) to compensate harmonics generated by battery charger. The presence of the harmonics leads to various problems and poor power quality.
Mahadan, Mohd Ezwan
core
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Design and Verification of a New Universal Active Filter Based on the Current Feedback Operational Amplifier and Commercial AD844 Integrated Circuit. [PDF]
Sensors (Basel), 2023 Chen HP +4 more
europepmc +1 more source