Results 131 to 140 of about 2,971,967 (301)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Active and Passive Flow Control of Turbomachines

International Journal of Rotating Machinery, 2013
N. Sitaram, K. Funazaki, Seyed G. Saddoughi   +2 more
doaj   +1 more source

Effects of Fixed Leading-Edge DBD Plasma Actuation on Pressure-Derived Lift of a NACA 0012 Airfoil

Aerospace
In this study, a dielectric barrier discharge (DBD) plasma actuator was placed at the leading edge of a National Advisory Committee for Aeronautics (NACA) 0012 airfoil to act on the separation initiation point, rather than on an already separated flow ...
Takafumi Yamada, Daiki Kishimoto
doaj   +1 more source

Sensitivity analysis of active flow control systems: operating parameters and configuration design [PDF]

, 2014
Bray T. P., Mark Jabbal, Valerio Tomasso
core   +2 more sources

Stability and control of compressible flows over a surface with concave-conves curvature [PDF]

The active control of spatially unstable disturbances in a laminar, two-dimensional, compressible boundary layer over a curved surface is numerically simulated. The control is effected by localized time-periodic surface heating.
Bayliss, A., Maestrello, L., Parikh, P., Turkel, E.   +3 more
core   +1 more source

Active Flow Control by Using Plasma Actuators

, 2016
Active flow control has recently received an increasing attention since it allows to directly manipulate the flow-field around a surface only when it is effectively requested. Aerodynamic plasma actuators supplied by a dielectric barrier discharge (DBD) can be used for this purpose. Usually, sinusoidal voltages in the range 5–50 kV peak and frequencies
openaire   +3 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Enhancing Flow Separation Control Using Hybrid Passive and Active Actuators in a Matrix Configuration

Aerospace
Efficient control of flow separation holds significant economic promise. This study investigates flow separation mitigation using an experimental platform featuring a combination of passive and active actuators arranged in a matrix configuration.
Songqi Li, Ping Zhang
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source