Results 131 to 140 of about 1,024,804 (310)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
New trends in active filters for improving power quality
, 1996 Since their basic compensation principles were proposed around 1970, active filters have been studied by many researchers and engineers aiming to put them into practical applications.
H. Akagi, Akagi, Hirofumi
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Active Flow Control by Using Plasma Actuators
, 2016 Active flow control has recently received an increasing attention since it allows to directly manipulate the flow-field around a surface only when it is effectively requested. Aerodynamic plasma actuators supplied by a dielectric barrier discharge (DBD) can be used for this purpose. Usually, sinusoidal voltages in the range 5–50 kV peak and frequencies
openaire +3 more sources
Active ways to control jet flows
E3S Web of ConferencesJet flows with active control methods are numerically studied. Axial, flapping and helical oscillations of the inlet velocity profile, transverse vibrations of the inlet boundary, and harmonic disturbances from sources located on the lateral boundaries are considered.
Yakovenko Sergey +2 more
openaire +2 more sources
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Active and Passive Flow Control of Turbomachines
International Journal of Rotating Machinery, 2013 N. Sitaram +2 more
doaj +1 more source
Effects of Tip Injection on a Turbofan Engine with Non-Invasive High-Speed Actuators
International Journal of Turbomachinery, Propulsion and PowerThis paper presents an analysis of the stability margin improvement (SMI), which is also known as stall margin improvement, achieved by continuous tip air injection.
Yannik Schäfer +3 more
doaj +1 more source
Experimental Investigation and Evaluation of Future Active Distribution Networks [PDF]
, 2010 The UK government’s policy to achieve a 20% renewable energy generation target by 2020, will require significant amounts of SSEG (Small-Scale Embedded Generation) to be connected.
Lyons, Padraig Fionnbharr +1 more
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