Results 51 to 60 of about 77,605 (280)

The TET3/GATA6 Axis Drives Lipid Metabolism and Therapeutic Vulnerabilities in Pancreatic Ductal Adenocarcinoma

open access: yesAdvanced Science, EarlyView.
The DNA demethylase TET3 drives lipid metabolic reprogramming in pancreatic ductal adenocarcinoma via a non‐catalytic mechanism. TET3 recruits histone deacetylases to repress GATA6, sustaining lipogenic enzyme expression and ferroptosis resistance.
Shuai Liu   +8 more
wiley   +1 more source

Obscuration-dependent evolution of Active Galactic Nuclei [PDF]

open access: yes, 2015
We aim to constrain the evolution of AGN as a function of obscuration using an X-ray selected sample of $\sim2000$ AGN from a multi-tiered survey including the CDFS, AEGIS-XD, COSMOS and XMM-XXL fields.
Aird, James   +11 more
core   +3 more sources

One‐Size‐Fits‐All: A Universal Binding Site for Single‐Layer Metal Cluster Self‐Assembly

open access: yesAdvanced Science, EarlyView.
A universal strategy enables the formation of single‐layer metal clusters (SLMC) across 21 elements by harnessing vacancy defects as binding sites. Crucially, synthesis occurs without reactive species, preventing site passivation and ensuring strong metal–surface bonding.
Emerson C. Kohlrausch   +16 more
wiley   +1 more source

NuSTAR Observation of the TeV-detected Radio Galaxy 3C 264: Core Emission and the Hot Accretion Flow Contribution

open access: yesThe Astrophysical Journal
3C 264 is one of the few FRI radio galaxies with detected TeV emission. It is a low-luminosity active galactic nucleus (LLAGN) and is generally associated with a radiatively inefficient accretion flow (RIAF).
Ka-Wah Wong   +6 more
doaj   +1 more source

Active Galactic Nuclei as High Energy Engines [PDF]

open access: yes, 1999
Active Galactic Nuclei are considered as possible sites of cosmic ray acceleration and some of them have been observed as high energy gamma ray emitters (Blazars). There naturally comes an appealing idea that the acceleration of the highest energy cosmic
Aharonian   +31 more
core   +3 more sources

Leukemic Cells Hijack Stromal Bioelectricity to Reprogram the Bone Marrow Niche via CaV1.2‐Dependent Mechanisms

open access: yesAdvanced Science, EarlyView.
Leukemic blasts induce membrane depolarization in mesenchymal stromal cells (MSCs), contributing to a dysfunctional niche that favors leukemia progression. Here, it is demonstrated that restoring the expression of CaV1.2 calcium channel in AML‐MSCs repolarizes their membrane potential, reprogramming them toward a healthy phenotype.
Ambra Da Ros   +11 more
wiley   +1 more source

Search and Characterization of Remnant Radio Galaxies in the XMM-LSS Deep Field

open access: yesThe Astrophysical Journal, 2023
The remnant phase of a radio galaxy is characterized by the cessation of active galactic nuclei activity, resulting in the jets ceasing to feed plasma to the radio lobes.
Sushant Dutta   +5 more
doaj   +1 more source

Cluster magnetic fields from active galactic nuclei

open access: yes, 2009
Active galactic nuclei (AGN) found at the centers of clusters of galaxies are a possible source for weak cluster-wide magnetic fields. To evaluate this scenario, we present 3D adaptive mesh refinement MHD simulations of a cool-core cluster that include ...
Ricker, P. M.   +2 more
core   +1 more source

Deep Learning‐Assisted Coherent Raman Scattering Microscopy

open access: yesAdvanced Intelligent Discovery, EarlyView.
The analytical capabilities of coherent Raman scattering microscopy are augmented through deep learning integration. This synergistic paradigm improves fundamental performance via denoising, deconvolution, and hyperspectral unmixing. Concurrently, it enhances downstream image analysis including subcellular localization, virtual staining, and clinical ...
Jianlin Liu   +4 more
wiley   +1 more source

NuSTAR Observes Two Bulgeless Galaxies: No Hard X-Ray AGN Detected in NGC 4178 or J0851+3926

open access: yesThe Astrophysical Journal, 2023
The discovery over the last several decades of low- and moderate-luminosity active galactic nuclei (AGNs) in disk-dominated galaxies—which show no “classical” bulges—suggests that secular mechanisms represent an important growth pathway for supermassive ...
Ryan W. Pfeifle   +7 more
doaj   +1 more source

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