Results 91 to 100 of about 102,749 (268)

MUC1 as a Survival Effector of Radiotherapy‐Induced Epithelial Hybrid States in Basal‐Like Breast Cancer

International Journal of Cancer, EarlyView.
Basal‐like breast cancer (BLBC) is aggressive and often exhibits inherent or acquired resistance to radiotherapy (RT), a primary treatment option. RT resistance is underpinned by molecular alterations, many of which are poorly understood. Here, RT‐induced transcriptomic changes were analyzed using bulk and spatial sequencing in a BLBC mouse model and ...
Garyfallia Pantelaiou‐Prokaki, Husam Bamahmoud, Nadine S. Georges, Shaishavi Jansari, Annika Jung, Daniela Grimm, Evangelos Prokakis, Fabian Alexander Gayer, Maryam Deldar, Christian Dullin, Julia Gallwas, Florian Wegwitz, Frauke Alves   +12 more
wiley   +1 more source

Blowing Star Formation Away in AGN Hosts (BAH). II. Investigating the Origin of the H2 Emission Excess in Nearby Galaxies with JWST MIRI

The Astrophysical Journal
We use James Webb Space Telescope Mid-Infrared Instrument Medium-resolution Spectrometer observations of 3C 293 (UGC 8782), CGCG 012-070 and NGC 3884 to investigate the origin of the H _2 emission.
Rogemar A. Riffel, Gabriel L. Souza-Oliveira, José Henrique Costa-Souza, Nadia L. Zakamska, Thaisa Storchi-Bergmann, Rogério Riffel, Marina Bianchin   +6 more
doaj   +1 more source

Arbuscular mycorrhizal fungal community abundance, functions, and symbiotic interactions revealed by root metatranscriptomes

iMetaOmics, EarlyView.
Paradigm shift: PCR‐free methods reveal 6–15‐fold higher arbuscular mycorrhizal (AM) fungal abundance than metabarcoding, exposing systematic underestimation across decades of research. Predictive power: AM fungal abundance serves as a community‐level trait that predicts crop yield under drought conditions.
Peilin Chen, John W. Taylor, Cheng Gao
wiley   +1 more source

Ginseng polysaccharides prevent mastitis through Lactobacillus murinus‐derived deoxycholic acid and TGR5 signaling

iMetaOmics, EarlyView.
Prebiotic Ginseng polysaccharides (GP) alleviate mastitis through selective enrichment of gut L. murinus, which elevates its anti‐inflammatory metabolite deoxycholic acid (DCA). Circulating DCA engages mammary epithelial TGR5 receptors, triggering the cAMP–PKA pathway to suppress NF‐κB/NLRP3‐mediated inflammation.
Zhijie Zheng, Huiying Liu, Sizhe Chen, Jianhui Gu, Sisi Cai, Xiang Liu, Raphaela I. Lau, Yao Zhang, Sunjae Lee, Xiaoyan Wang, Kewei Fan, Xiaole Yin, Hein Min Tun, Renyou Gan, Haichong Wu, Qi Su   +15 more
wiley   +1 more source

The Remarkable Predictive Power of Infrared Data of Blazars

The Astrophysical Journal
Blazars are the brightest and most abundant persistent sources in the extragalactic γ -ray sky. Due to their significance, they are often observed across various energy bands, where the data of which can be used to explore potential correlations between ...
P. Giommi, N. Sahakyan, D. Israyelyan, M. Manvelyan   +3 more
doaj   +1 more source

Progress of metabolomics‐centric multi‐omics research in medicine

iMetaOmics, EarlyView.
The graphical abstract illustrates a holistic roadmap for metabolomics‐centric multi‐omics integration in medical research. The upper panel depicts the technological transition from traditional bulk analysis to high‐resolution single‐cell and spatial methodologies, specifically addressing inherent challenges such as molecular complexity and dynamic ...
Ziyi Wang, Shiwen Deng, Xiaoxu Wang, Xiao Chang, Na Guo, Peng Chen, Hongjun Yang   +6 more
wiley   +1 more source

Probing the Physical Origin of the Balmer Decrement in the Broad-line Region of Nearby Active Galactic Nuclei via Spectral Variability

The Astrophysical Journal
To investigate the physical origin of the Balmer decrement in the broad-line region of active galactic nuclei (AGNs), we measure the temporal variability of the fluxes of the broad H β and H α emission lines using multiepoch spectroscopic data of low ...
Suyeon Son, Minjin Kim, Luis C. Ho, Ruancun Li   +3 more
doaj   +1 more source

An autonomous and economical benthic incubation chamber for measuring dissolved oxygen fluxes in shallow, low‐flow environments

Limnology and Oceanography: Methods, EarlyView.
Abstract Benthic incubation chambers enclose a known volume of water overlying a known area to measure water chemistry changes and are typically used to quantify the metabolic activity of benthic organisms or communities. Here we present an economical benthic incubation chamber for shallow, low‐flow environments, built using off‐the‐shelf components ...
Luke D. Groff, Peter Berg, Karen J. McGlathery   +2 more
wiley   +1 more source

Properties of Voids and Void Galaxies in the TNG300 Simulation

The Astrophysical Journal
We investigate the properties of voids and void galaxies in the TNG300 simulation. Using a luminous galaxy catalog and a spherical void-finding algorithm, we identify 5078 voids at redshift z = 0.
Olivia Curtis, Bryanne McDonough, Tereasa G. Brainerd   +2 more
doaj   +1 more source

The Host Galaxy Fluxes of Active Galaxy Nuclei Are Generally Overestimated by the Flux Variation Gradient Method

Universe
In terms of the variable nature of normal active galaxy nuclei (AGN) and luminous quasars, a so-called flux variation gradient (FVG) method has been widely utilized to estimate the underlying non-variable host galaxy fluxes.
Minxuan Cai, Zhen Wan, Zhenyi Cai, Lulu Fan, Junxian Wang   +4 more
doaj   +1 more source