Results 91 to 100 of about 3,880,038 (272)

Reward Maximisation through Discrete Active Inference [PDF]

, 2022
Active inference is a probabilistic framework for modelling the behaviour of biological and artificial agents, which derives from the principle of minimising free energy.
Parr, Thomas, Da Costa, Lancelot, Smith, Ryan, Sajid, Noor, Friston, Karl   +4 more
core  

Active Inference and Intentional Behavior

Neural Computation
Abstract Recent advances in theoretical biology suggest that key definitions of basal cognition and sentient behavior may arise as emergent properties of in vitro cell cultures and neuronal networks. Such neuronal networks reorganize activity to demonstrate structured behaviors when embodied in structured information landscapes.
Karl J. Friston, Tommaso Salvatori, Takuya Isomura, Alexander Tschantz, Alex B. Kiefer, Tim Verbelen, Magnus T. Koudahl, Aswin Paul, Thomas Parr, Adeel Razi, Brett J. Kagan, Christopher L. Buckley, Maxwell J. D. Ramstead   +12 more
openaire   +4 more sources

Active Bayesian Causal Inference

Advances in Neural Information Processing Systems 35, 2022
Causal discovery and causal reasoning are classically treated as separate and consecutive tasks: one first infers the causal graph, and then uses it to estimate causal effects of interventions. However, such a two-stage approach is uneconomical, especially in terms of actively collected interventional data, since the causal query of interest may not ...
Christian Toth, Lars Lorch, Christian Knoll 0002, Andreas Krause 0001, Franz Pernkopf, Robert Peharz, Julius von Kügelgen   +6 more
openaire   +5 more sources

Intelligent Active Vibration Control for a Flexible Beam System [PDF]

, 2004
YesThis paper presents an investigation into the development of an intelligent active vibration control (AVC) system. Evolutionary Genetic algorithms (GAs) and Adaptive Neuro-Fuzzy Inference system (ANFIS) algorithms are used to develop mechanisms of an ...
Yu, H., Dahal, Keshav P., Hossain, M. Alamgir, Madkour, A.A.M.   +3 more
core   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Degeneracy and Redundancy in Active Inference

Cerebral Cortex, 2020
AbstractThe notions of degeneracy and redundancy are important constructs in many areas, ranging from genomics through to network science. Degeneracy finds a powerful role in neuroscience, explaining key aspects of distributed processing and structure–function relationships in the brain.
Noor Sajid, Thomas Parr, Thomas M Hope, Cathy J Price, Karl J Friston   +4 more
openaire   +3 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source