Results 111 to 120 of about 649,550 (269)

Likelihood reweighting methods to reduce potential bias in noninferiority trials which rely on historical data to make inference

, 2013
It is generally believed that bias is minimized in well-controlled randomized clinical trials. However, bias can arise in active controlled noninferiority trials because the inference relies on a previously estimated effect size obtained from a ...
Chu, Jianxiong, Nie, Lei, Rubin, Daniel, Zhang, Zhiwei   +3 more
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Visual Causal Feature Learning [PDF]

, 2015
We provide a rigorous definition of the visual cause of a behavior that is broadly applicable to the visually driven behavior in humans, animals, neurons, robots and other perceiving systems. Our framework generalizes standard accounts of causal learning
Chalupka, Krzysztof, Eberhardt, Frederick, Perona, Pietro   +2 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

TCP Congestion Control Identification [PDF]

, 2014
Transmission Control Protocol (TCP) carries most of the traffic on the Internet these days. There are several implementations of TCP, and the most important difference among them is their mechanism for controlling congestion.
Ahmed, Mohammed
core  

The Active Inference Institute & Active Inference Ecosystem

This document surveys the current state of The Active Inference Institute and The Active Inference Ecosystem, in the context of our current and future directions. As embodied agents, we aim to update our decisions, goals and predictions as an institute by actively gathering (sampling) insights (observations) from our members.
Active Inference Institute, Vyatkin, Alex, Mikhailova, Alexandra, Hiott, Andrea, Pashea, Andrew, Elers, Ben, Berkers, Bert, Knight, Bleu, Fields, Chris, Whittet, Dan, Friedman, Daniel, Ticklẽs, Déan, Paterson, Fraser, Stubbs, Gareth, Grimm, Holly, Smekal, Jakub, Cooper, Jeremy, Boik, John, Burian, Libor, Albarracin, Mahault, Iennaco, Maria Luiza, Brown, Matthew, Thacker, Mick, Gilli, Peter, Kaufmann, Rafael, Cordes, RJ, Henry, Ryan, Ramesh, Sandeep, David, Scott, Alvarado, Sebastian, Baker, Zach   +30 more
openaire   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Exact active subspace Metropolis-Hastings, with applications to the Lorenz-96 system [PDF]

, 2017
We consider the application of active subspaces to inform a Metropolis-Hastings algorithm, thereby aggressively reducing the computational dimension of the sampling problem. We show that the original formulation, as proposed by Constantine, Kent, and Bui-
Constantine, Paul G., Schuster, Ingmar, Sullivan, T. J.   +2 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source