Results 111 to 120 of about 3,880,038 (272)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Active Inference Tree Search in Large POMDPs [PDF]
, 2023 The ability to plan ahead efficiently is key for both living organisms and artificial systems. Model-based planning and prospection are widely studied in cognitive neuroscience and artificial intelligence (AI), but from different perspectives--and with ...
Gregoretti, Francesco +3 more
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Simulating Active Inference Processes by Message Passing
Frontiers in Robotics and AI, 2019 The free energy principle (FEP) offers a variational calculus-based description for how biological agents persevere through interactions with their environment.
Thijs W. van de Laar +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
The Active Inference Institute & Active Inference Ecosystem
This document surveys the current state of The Active Inference Institute and The Active Inference Ecosystem, in the context of our current and future directions. As embodied agents, we aim to update our decisions, goals and predictions as an institute by actively gathering (sampling) insights (observations) from our members.
Active Inference Institute +30 more
openaire +2 more sources
A Minimal Active Inference Agent
CoRR, 2015 Research on the so-called "free-energy principle'' (FEP) in cognitive neuroscience is becoming increasingly high-profile. To date, introductions to this theory have proved difficult for many readers to follow, but it depends mainly upon two relatively simple ideas: firstly that normative or teleological values can be expressed as probability ...
Simon McGregor +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Active Inference, Novelty and Neglect [PDF]
, 2018 In this chapter, we provide an overview of the principles of active inference. We illustrate how different forms of short-term memory are expressed formally (mathematically) through appealing to beliefs about the causes of our sensations and about the actions we pursue.
Parr, T, Friston, KJ
openaire +3 more sources
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source