Advanced Science, EarlyView.This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu +10 more
wiley +1 more source
Assessing the Efficacy of the INTELLECT Cognitive Behavioral Therapy Mobile App for Anxiety and Depressive Symptoms Among At-Risk Japanese Employees: Randomized Controlled Trial. [PDF]
JMIR Mhealth UhealthYokomitsu K +3 more
europepmc +1 more source
Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo
Advanced Science, EarlyView.As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao +12 more
wiley +1 more source
Keeping Pace or Falling Behind? The Depth of Latin American Trade Agreements
Applied Economic Perspectives and Policy, EarlyView.ABSTRACT This article examines whether Latin American countries are keeping pace with global trends in trade agreement depth or falling behind. Using 681 agreements (1970–2019), we develop the Depth Index of Trade Agreements (DITA) to weight provisions endogenously through factor analysis based on co‐occurrence patterns.
Raphael Gomes da Silva +2 more
wiley +1 more source
Do personality traits explain the adjustment? A study of civilian victims of war in Ukraine. [PDF]
Eur J PsychotraumatolOleś P +4 more
europepmc +1 more source
Farmers' Preferences for Gene Editing Crops and Influencing Factors
Applied Economic Perspectives and Policy, EarlyView.ABSTRACT Gene editing (GE) is gaining momentum worldwide, but limited data on UK farmers' preferences hinders our understanding of its potential impact amid deregulation debates. Based on a survey of 200 English arable farmers, we employ a Latent Class Analysis and Multinomial Logit regressions to investigate current preferences for GE crops.
Bertolozzi‐Caredio Daniele +1 more
wiley +1 more source
Stigma Resistance by Adult Self-Advocates With Intellectual Disabilities. [PDF]
J Appl Res Intellect DisabilSarras N +3 more
europepmc +1 more source
AGING MEDICINE, EarlyView.The Setting Standards for Elderly Hospice Care Wards are crucial for meeting urgent elderly patient needs, enhancing hospice care quality, and advancing China's humanized elderly health system. This Standard specifies the configuration requirements for geriatric hospice care wards in terms of ward configuration, staffing models, age‐appropriate ...
Yinan Wu +12 more
wiley +1 more source
Cortical travelling waves relate to variation in personality traits. [PDF]
Imaging Neurosci (Camb)Bailey NW, Pacheco LB, Smillie LD.
europepmc +1 more source
Beneficial Body Mass Index for Age‐Related Kidney Function in Males and Females
AGING MEDICINE, EarlyView.The impact of BMI on age‐related kidney function decline is highly sex‐ and age‐dependent. Normal BMI (18.5–25 kg/m2) is associated with better age‐related kidney function in all‐aged males and females older than 45 years. ABSTRACT Objectives Kidney function declines with aging, leading to a high prevalence of age‐related disease.
Lu Wei +7 more
wiley +1 more source