Results 31 to 40 of about 8,804 (263)

From the contemplative to the unbalanced intellect: Schopenhauer, Nietzsche and Piaget

Voluntas, 2018
The discernment between good and evil can be rightfully considered the central concern of Philosophy, but its pursuit requires a complex combination of mature cognitive, linguistic and social skills.
Tristan Guillermo Torriani
doaj   +3 more sources

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

STUDYING THE RELATIONSHIP BETWEEN SOCIAL INTELLECT AND COPING STRATEGIES (BY THE EXAMPLE OF GROUPS WITH DIFFERENT LEVELS OF SOCIAL INTELLECT)

Sovremennye Issledovaniâ Socialʹnyh Problem, 2018
Relevance. The interrelation between coping strategies and social intellect is now a problem. Few research efforts are devoted to this linkage, and the results of these investigations are contradictory. Goal.
Tatiana Leonidovna Smorkalova
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

A Comparative Study of Mulla Sadra and Henry Corbin: Their Views concerning the Impact of Revealed Teachings on Human Being [PDF]

Religious Inquiries, 2019
In the Islamic tradition, Mulla Sadra is foremost among the philosophers who have dealt with the issue of prophecy from all three theological, philosophical, and mystical perspectives.
Mahnaz Osooli, Enshaallah Rahmati
doaj   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Perfect Man’s Epistemological Process on Curves of Descent and Ascent “ViewPoint of Mulla-Sadra” [PDF]

حکمت معاصر, 2012
In this paper presents an Epistemological Process of Mulla-Sadra’s transcendental wisdom. He introduces First Intellect as Perfect Man’s light that is first effusion and emanation’s source of vertical intelligences in gradational degrees. On his Approach
Maryam Saneapour
doaj  

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

El diverso tratamiento del intelecto agente en la Escuela Franciscana del s. XVI / The different treatment of intellect agent in the Franciscan School on XVIth century

Cauriensia, 2016
En este trabajo se estudia y valora el diverso tratamiento que cuatro doctores franciscanos del siglo XVI ofrecieron sobre la índole del intelecto agente en compara-ción con el posible: Franz Titelmans y Jacobo Malafossa, que no se pronunciaron ...
Juan Fernando Sellés Dauder
doaj   +2 more sources

Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions marked by iron‐laden microglia and macrophages. Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, suppresses acute MS activity, but its effect on PRLs remains unclear. In a longitudinal study of 29 ocrelizumab‐treated patients with at least
Kimberly H. Markowitz, Neha V. Safi, Iliana Pliska‐Bloch, Ulrike W. Kaunzner, Ha Luu, Yi Wang, Thanh D. Nguyen, Sandra Hurtado Rúa, Susan A. Gauthier   +8 more
wiley   +1 more source