Results 41 to 50 of about 181,510 (310)

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Perfect Man’s Epistemological Process on Curves of Descent and Ascent “ViewPoint of Mulla-Sadra” [PDF]

حکمت معاصر, 2012
In this paper presents an Epistemological Process of Mulla-Sadra’s transcendental wisdom. He introduces First Intellect as Perfect Man’s light that is first effusion and emanation’s source of vertical intelligences in gradational degrees. On his Approach
Maryam Saneapour
doaj  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

El diverso tratamiento del intelecto agente en la Escuela Franciscana del s. XVI / The different treatment of intellect agent in the Franciscan School on XVIth century

Cauriensia, 2016
En este trabajo se estudia y valora el diverso tratamiento que cuatro doctores franciscanos del siglo XVI ofrecieron sobre la índole del intelecto agente en compara-ción con el posible: Franz Titelmans y Jacobo Malafossa, que no se pronunciaron ...
Juan Fernando Sellés Dauder
doaj   +2 more sources

Blogging on the ice: Connecting audiences with climate-change sciences [PDF]

, 2013
Scientists working in Antarctica have recognized the need to counteract problems associated with mainstream media's treatment of the climate-change crisis.
Thorsen, Einar
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Konsep Pengetahuan Dalam the Idea of a University Dari John Henry Newman [PDF]

, 2003
For Newman, knowledge is an exercise of the intellect to develop the habit of viewing the objects as a unity, like an encyclopaedia, or a circle or a concert.
Balela, Y. S. (Yoseph)
core  

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Meme Pools, World 3, and Averroës's Vision of Immortality

Zygon, 1998
Dawkins's concept of the meme pool, essentially equivalent to Popper's World 3, is considered as an expression in modern terms for what Averroës knew as the active intellect, an immortal entity feeding into, or even creating, the passive intellect of ...
doaj   +2 more sources

Is Spinoza’s theory of Finite Mind Coherent? – Death, Affectivity and Epistemology in the Ethics [PDF]

, 2017
In this paper I examine the question whether Spinoza can account for the necessity of death. I argue that he cannot because within his ethical intellectualist system the subject cannot understand the cause of her death, since by understanding it renders ...
Toth, Oliver Istvan
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