Results 71 to 80 of about 8,804 (263)

The nature and workings of sacred intellect from the perspective of Avicenna

open access: yesJournal of Philosophical Investigations, 2017
Sacred intellect in Avicenna, a degree of rationality in which the highest form of communication is done with the intellectual world. Reasonable time to the times of human rationality is achieved without difficulty, pain and time, only be achieved by ...
Einollah Khademi   +1 more
doaj  

The motives of learning activity and intellect of students

open access: yesPsichologija, 1984
The progress in studies is conditioned by the level of functional and motivational components and their correlation. Peculiarities of visual memory, space imagination and thinking of students of physics and technical specialities are analysed in this work.
openaire   +2 more sources

Genetic Diagnosis and Discovery Enabled by Large Language Models

open access: yesAdvanced Science, EarlyView.
We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu   +25 more
wiley   +1 more source

Phantasia et nous pathêtikos

open access: yesMethodos, 2016
Proclus, in his theory of projection of the geometrical figures, is the first one to assimilate the phantasia (imagination) with the nous pathêtikos (passive intellect) evoked furtively by Aristote in De anima III, 5. While maintaining this assimilation,
Milan Otal
doaj   +1 more source

Single‐Cell Transcriptomic Atlases of Camels and Cattle Unravel Molecular Evolution of Digestive and Metabolic Systems

open access: yesAdvanced Science, EarlyView.
We generated multi‐tissue single‐cell transcriptomic atlases of camels and cattle, uncovering conserved and lineage‐specific cellular features across digestive and metabolic systems. Cross‐species comparisons revealed the evolutionary origin of the camel glandular sac and identified novel cell populations linked to physiological specialization ...
Tao Shi   +22 more
wiley   +1 more source

Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling

open access: yesAdvanced Science, EarlyView.
Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu   +20 more
wiley   +1 more source

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

open access: yesAmerican Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei   +4 more
wiley   +1 more source

Critical Limitations in Cryogenic Laser Cooling of Solids: Symmetry‐Related Fluorescence Trapping and Condensation‐Induced Parasitic Heating

open access: yesAdvanced Science, EarlyView.
This study uncovers two overlooked bottlenecks in cryogenic laser cooling of solids: symmetry‐driven fluorescence trapping and water vapor condensation. We demonstrate that breaking sample symmetry enhances fluorescence escape, while condensation dominates parasitic heating below 135 K.
Biao Zhong   +5 more
wiley   +1 more source

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

open access: yesAdvanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao   +8 more
wiley   +1 more source

Fârâbî’de Faal Aklın Siyasal Fonksiyonu ve Meşruiyetin Ontolojik Temeli

open access: yesDini Araştırmalar
Fârâbî’nin siyaset felsefesi, metafizik ile siyasî düşünceyi birbirine bağlı, karşılıklı olarak temellendiren ve sınırlarını belirleyen bir sistem bütünlüğü içinde ele alır.
Bahar Koca
doaj   +1 more source

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