Results 71 to 80 of about 8,949 (257)

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Anti‐CD19 CAR T Cells in Autoimmune Encephalitis: Inflammation Controlled, Neurodegeneration Unchecked?

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Just recently, successful chimeric antigen receptor (CAR) T cell therapy was reported in the first patient with refractory, anti‐diacylglycerol lipase alpha (DAGLA) antibody‐mediated autoimmune encephalitis, achieving partial clinical remission.
Dimitrios Mougiakakos, Marwa Al‐Dubai, Denise Walther, Dominic Borie, Jan D. Lünemann, Marc Pawlitzki, Sven G. Meuth, Solveig Henneicke, Stefan Vielhaber, Stefanie Schreiber   +9 more
wiley   +1 more source

Rational Explanation of the Relationship between the Material Intellect and the Active Intellect from the Perspective of Averroes

International Journal of Islamic Thought, 2015
The relationship between the material intellect and the active intellect from Averroes’ perspective is an important and yet complicated part of his philosophy. His views on these issues are ambiguous since they are derived from the Aristotle’s theories which seem obscure in this regard. The aim of the present study is to discover Averroes’ final theory
openaire   +2 more sources

Recurrent Hypothermia and Autonomic Dysfunction Secondary to Shapiro Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 44‐year‐old man presented with recurrent hypothermia, diaphoresis and hypertension. Extensive investigation for infectious, inflammatory, metabolic and endocrine aetiologies was negative. MR scan of the brain demonstrated no lesions but revealed callosal dysgenesis, consistent with Shapiro syndrome.
Naveen Kumar, Jeremy Johnson, Susanne Watkins, Eoin Mulroy   +3 more
wiley   +1 more source

Wychowanie intelektu jako celowościowe uporządkowanie jego funkcji

Horyzonty Wychowania, 2009
Educating man is essentially connected with educating intellect. And this means shaping it, cultivating, obtaining a degree of culture. In philosophical literature concerning the issue of intellect there is terminological chaos.
Mikołaj Krasnodębski, Michał Zemnrzuski   +1 more
doaj  

The alleged activity of active intellect: A wild goose chase or a puzzle to be solved?

Philosophical Problems in Science (Zagadnienia Filozoficzne w Nauce), 2014
Trying to describe the activity of Aristotle’s active intellect, we will sooner or later realize that we cannot find its right description, because Aristotle did not provide for one. He left us with many irreconcilable statements and questions with no answers.
openaire   +3 more sources

Metabolic and Microvascular Risk Factors Associated With Brain Health in Type 1 Diabetes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We examined relationships between metabolic factors, microvascular complications, and brain health in adults with type 1 diabetes. Fifty‐one adults were assessed for metabolic risk factors, microvascular complications, and cognitive function, with a subset completing brain MRI.
Jihyun Park, Emily J. Koubek, Richard Beare, Lynn Ang, Brian C. Callaghan, Rodica Pop‐Busui, Eva L. Feldman, Evan L. Reynolds   +7 more
wiley   +1 more source

The nature and workings of sacred intellect from the perspective of Avicenna

Journal of Philosophical Investigations, 2017
Sacred intellect in Avicenna, a degree of rationality in which the highest form of communication is done with the intellectual world. Reasonable time to the times of human rationality is achieved without difficulty, pain and time, only be achieved by ...
Einollah Khademi, Arefeh Poushian Jouybari   +1 more
doaj  

Human Knowledge Acquisition Process In the Philosophy of Sadr-Al-Motaalehin Shirazi [PDF]

حکمت معاصر, 2014
Abandoningtheactive intellectas the main cause of perceptual forms, is there any different approach, based ontheprinciples ofSadra’s philosophy, to explain the process of human knowledge obtaining?
Mohammadreza Balanian, Morteza Hajihosseini   +1 more
doaj  

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source