Results 41 to 50 of about 252,192 (310)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Internal Rotor Actuation and Magnetic Bearings for the Active Control of Rotating Machines

Actuators, 2022
Passive rotors are often limited in rotational speed due to bearing constraints, stability and excessive vibration levels. To address the vibration issue, Active Magnetic Bearings (AMBs) levitating the rotor with a magnetic field can be used.
Gauthier A. Fieux, Nicola Y. Bailey, Patrick S. Keogh   +2 more
doaj   +1 more source

Control of Active Magnetic Bearings

Strojnícky časopis - Journal of Mechanical Engineering
Abstract This article presents a model of rigid rotor supported by active magnetic bearings (AMB). Mathematical formulation of magnetic forces generated by AMB has been developed. Equations of motion of rigid rotor supported by controllable AMB with and without control law are presented.
Magdolen Luboš, Kevický Igor, Danko Ján, Sammarah George, Milesich Tomáš   +4 more
openaire   +2 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Three axis attitude control system [PDF]

, 1988
A three-axis attitude control system for an orbiting body comprised of a motor driven flywheel supported by a torque producing active magnetic bearing is described.
Studer, Philip A.
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The Influence of Axial-Bearing Position of Active Magnetic Suspension Flywheel Energy Storage System on Vibration Characteristics of Flywheel Rotor

Actuators
This study introduces a flywheel rotor support structure for an active magnetic suspension flywheel energy storage system. In this structure, there is an axial offset between the axial-bearing position and the mass-center of the flywheel rotor, which ...
Lei Wang, Tielei Li, Zhengyi Ren
doaj   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Development of an Active Micromagnetic Bearing with a 300 μm Outer Diameter Permanent Micromagnet

Actuators
Micromachines, MEMS and actuators suffer from much more significant relative friction and wear issues than their equivalent macroscopic devices. Active magnetic bearings can be a good option to mitigate friction issues; however, their construction at ...
Efren Diez-Jimenez, Miguel Fernandez-Munoz, Rodrigo Garcia-Gonzalez, Hugo Rodriguez-Bodoque, Jesus del-Olmo-Anguix, Angel Villacastin-Sanchez, Gabriele Barbaraci, Emiliano Pereira, Oscar Manzano-Narro, Diego Lopez-Pascual, Ignacio Valiente-Blanco   +10 more
doaj   +1 more source

Analysis and Control of Slotless Self-Bearing Motor

Actuators, 2019
A self-bearing motor (SBM) is an electric motor with a magnetically integrated bearing function, that is, it can provide levitation and rotation simultaneously as a single actuator.
Huy Phuong Nguyen, Xuan Bien Nguyen, Trung Tuyen Bui, Satoshi Ueno, Quang Dich Nguyen   +4 more
doaj   +1 more source