Results 111 to 120 of about 3,491,013 (300)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Development and application of radar reflectometer using micro to infrared waves

Advances in Physics: X, 2018
Progress in microwave and millimeter-wave technologies has made possible advanced diagnostics for application to various fields, including radio astronomy, alien substance detection, plasma diagnostics, airborne and space-borne imaging radars called as ...
A. Mase, Y. Kogi, D. Kuwahara, Y. Nagayama, N. Ito, T. Maruyama, H. Ikezi, X. Wang, M. Inutake, T. Tokuzawa, J. Kohagura, M. Yoshikawa, S. Shinohara, A. Suzuki, F. Sakai, M. Yamashika, B. J. Tobias, C. Muscatello, X. Ren, M. Chen, C. W. Domier, N. C. Luhmann   +21 more
doaj   +1 more source

The MAORY first-light adaptive optics module for E-ELT

, 2015
The MAORY adaptive optics module is part of the first light instrumentation suite for the E-ELT. The MAORY project phase B is going to start soon.
Ragazzoni R., De Caprio V., Agapito G., Cortecchia F., Delboulbe A., Henault F., Riva M., Giro E., Bonaglia M., Lauria M., Pareschi G., Biliotti V., Briguglio R., Verinaud C., Esposito S., Busoni L., Spano P., Giordano C., Rochat S., Ramsay S., Bregoli G., Oberti S., Ferruzzi D., Ventura N., Arcidiacono C., Lafrasse S., Baruffolo A., Cascone E., Rabou P., Carbonaro L., Felini C., Schreiber L., Bellazzini M., Foppiani I., Xompero M., Roussel F., De Rosa A., Fiorentino G., De Pascale M., Ciliegi P., Ghigo M., Sztefek M. -H., Saracco P., Spavone M., Fini L., Magnard Y., Maurel D., Puglisi A., Roux A., Maiorano E., Le Coarer E., Di Rico G., Riccardi A., Morgante G., Cosentino G., Mapelli M., Moulin T., Fantinel D., Butler R. C., Jocou L., Lombini M., Marchetti E., Gluck L., Michaud L., Feautrier P., Zerbi F. M., Carlotti A., Diolaiti E., Ricciardi S., Abicca R., Mannucci F., Salasnich B., Zins G., Correia J. -J., Patti M., Stadler E., Casali M., Kerber F., Brissaud O., Del Vecchio C.   +79 more
core   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Progress in laser active detection technology based on the cat’s eye effect

Results in Physics
Laser active detection technology utilizing the cat’s eye effect is widely applied in rapid reconnaissance, positioning, and target information acquisition.
Xinchen Du, Chunrui Wang, Haoran Zhou, Yunfeng Zhang, Jin Guo, Fei Chen   +5 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Transportation Development Division, Active Transportation Section [PDF]

This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from PDF caption (viewed on April 11, 2014)Mode of ...

core