Results 141 to 150 of about 7,204,380 (286)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Play in Chinese kindergartens : teachers' perceptions and practices [PDF]

Play is widely recognized as a natural ability and fundamental right of children. In educational settings, the idea of integrating play into early childhood education to promote children’s learning and development has been continually advocated by ...
Yang, Yanjuan
core  

Play in Urban Spaces for Health [PUSH]: Designing play into urban environments for health and wellbeing [PDF]

This research developed the foundation for PUSH (Play in Urban Spaces for Health), a programme applying Forest School principles to regenerated urban spaces for regular outdoor play among 4-7-year-olds.
Christie, Nicola, Midouhas, Emily, Ranken, Emily, Van Herwegen, Jo, Hauari, Hanan, Cameron, Claire   +5 more
core   +1 more source

Guided Active Play Promotes Physical Activity and Improves Fundamental Motor Skills for School-Aged Children. [PDF]

J Sports Sci Med, 2021
Moghaddaszadeh A, Belcastro AN.
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Playing and being well: A review of recent research into children’s play, social policy and practice, with a focus on Wales (summary version)

Commissioned by Play Wales, this extensive litertature review considers contemporary research into childhood studies, relevant policy studies, the relationship between playing and being well, children's play patterns and examples of interventions to ...
Tawil, Ben, Russell, Wendy K, Barclay, Mike   +2 more
core  

Psychometric Properties of the Persian Version of Children’s Active Play Imagery Questionnaire

Annals of Applied Sport Science, 2017
Objectives. The purpose of this study was to determine the validity and reliability of the Persian version of the children’s active play imagery questionnaire. Methods.
Vali Ollah Kashani, Behroz Gol Mohamadi, Mansoureh Mokaberian   +2 more
doaj  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Playing and being well: A review of recent research into children’s play, social policy and practice, with a focus on Wales

Commissioned by Play Wales, this extensive literature review considers contemporary research into childhood studies, relevant policy studies, the relationship between playing and being well, children's play patterns and examples of interventions to ...
Tawil, Ben, Russell, Wendy K, Barclay, Mike   +2 more
core