Does an active play standard change childcare physical activity and healthy eating policies? A natural policy experiment. [PDF]
BMC Public Health, 2022 Tugault-Lafleur CN +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
"Children are precious cargo; we don't let them take any risks!": Hearing from adults on safety and risk in children's active play in schools: a systematic review. [PDF]
Int J Behav Nutr Phys Act, 2022 Jerebine A +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Friday Night Four Play League Banquet and Awards program
, 1997 This program is from the Friday Night Four Play League's annual awards banquet in 1997, the ninth banquet of the league. The program details the names of those running the league for the season, a schedule of events, and the league's budget from the ...
Friday Night Four Play League
core
Perspectives of infant active play: a qualitative comparison of working versus stay-at-home parents. [PDF]
BMC Public Health, 2021 Snyder K, Rech JP, Masuda K, Dinkel D.
europepmc +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Ecological validity of the PERF-FIT: correlates of active play, motor performance and motor skill-related physical fitness. [PDF]
Heliyon, 2021 Doe-Asinyo RX, Smits-Engelsman BCM.
europepmc +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Feasibility of the Go2Play Active Play intervention for increasing physical and social development in children with intellectual disabilities. [PDF]
Pilot Feasibility Stud, 2021 McGarty A +6 more
europepmc +1 more source