Results 111 to 120 of about 7,204,380 (286)

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Article 31 Action Pack Children's Rights and Children's Play : Resources for Action to Implement Article 31 of the United Nations Convention on the Rights of the Child

, 2023
The right rest and leisure, to engage in play is usually missing from any discussions of children's rights. It is all too easy to fall into the trap of thinking only of those rights which are about protections; from poverty, from war and from abuse of ...
Shier, Harry, Hart, Roger, PLAY-TRAIN
core  

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Unstructured play with active equipment enhances moderate-to-vigorous physical activity in children

Sport TK
This study examined the impact of a daily 25-minute unstructured physical activity (PA) break on the PA levels of children aged 7–9 years. Recess periods provide valuable opportunities to boost PA and counteract sedentary behaviors, especially when ...
Nguyen Huu Tri, Nguyen Quoc Tram, Trinh Thi Thanh Minh, Nguyen Thanh Trung   +3 more
doaj   +1 more source

Physical environment features that predict outdoor active play can be measured using Google Street View images. [PDF]

Int J Health Geogr, 2023
Boyes R, Pickett W, Janssen I, Swanlund D, Schuurman N, Masse L, Han C, Brussoni M.   +7 more
europepmc   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Junk Journeys and Urban Play: Unearthing Auckland’s DIY Adventures Through the Eyes of Street Play Makers

, 2023
This paper embarks on an exploration into the vibrant world of do-it-yourself (DIY) play practices within the urban milieu of Tāmaki Makaurau previously known as Auckland, Aotearoa New Zealand.
Zhang, Linda, Ben-Dror, Adam, Fu, Wins, Berthelsen, Chris, Rachev, Rumen, Smith, James   +5 more
core  

Adoption, implementation, and sustainability of early childhood feeding, nutrition and active play interventions in real-world settings: a systematic review. [PDF]

Int J Behav Nutr Phys Act, 2023
Gelman R, Whelan J, Spiteri S, Duric D, Oakhill W, Cassar S, Love P.   +6 more
europepmc   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source