Results 101 to 110 of about 7,204,380 (286)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Routledge International Handbook of Play, Therapeutic Play and Play Therapy

, 2020
Routledge International Handbook of Play, Therapeutic Play and Play Therapy is the first book of its kind to provide an overview of key aspects of play and play therapy, considering play on a continuum from generic aspects through to more specific ...
Jennings, Sue, Holmwood, Clive
core   +1 more source

First report card on physical activity for children and adolescents in Slovakia: a comprehensive analysis, international comparison, and identification of surveillance gaps

Archives of Public Health
Background National surveillance of physical activity (PA) is essential to establish public health policy actions for PA promotion and evaluation, thereby promoting accountability.
Peter Bakalár, Lenka Hnidková, Beáta Ružbarská, Pavel Ružbarský, Terézia Kovalik Slančová, Jaroslava Kopčáková, Michaela Kostičová, Aleš Gába   +7 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

2025 position statement on active outdoor play: process and methodology

International Journal of Behavioral Nutrition and Physical Activity
Background The 2015 Position Statement on Active Outdoor Play highlighted the benefits of active outdoor play for child health and development and had significant impact on public policy, law, philanthropy, and research in Canada and internationally.
Louise de Lannoy, Eun-Young Lee, Suryeon Ryu, Olivia Lopes, Joshua S. Cheruvathur, Anujah Thankarajah, Dina Adjei Boadi, Isabel de Barros, Scott Duncan, Maeghan E. James, Lærke Mygind, Robyn Monro Miller, Leigh M. Vanderloo, Po-Yu Wang, Laura Heather, Mark S. Tremblay   +15 more
doaj   +1 more source

“Losing access to outdoor spaces was the biggest challenge for children to be healthy”: pandemic restrictions and community supports for children’s movement in Nova Scotia

Frontiers in Public Health
IntroductionHealth-focused communities can promote physical activity for children by providing them with safe and supportive environments to move.
Maggie Locke, Becky Feicht, Becky Feicht, Michelle R. Stone, Michelle R. Stone, Emily Burke, Emily Burke, Laurene Rehman, Sara F. L. Kirk, Sara F. L. Kirk, Guy Faulkner, Sarah A. Moore, Sarah A. Moore, Sarah A. Moore   +13 more
doaj   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source