Results 91 to 100 of about 7,204,380 (286)

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

Editorial: The Effects of Climate Change and Environmental Factors on Exercising Children and Youth

open access: yesFrontiers in Sports and Active Living, 2021
Shawnda A. Morrison   +4 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

School Libraries Play an Active, Transformational Role in Student Learning and Achievement

open access: yesEvidence Based Library and Information Practice, 2006
A review of: Todd, Ross J. “Student Learning Through Ohio School Libraries: A Summary of the Ohio Research Study.” Ohio Educational Library Media Association 15 Dec. 2003. Ohio Educational Library Media Association (OELMA), 2004. 15 Nov. 2006 http://
Gayle Bogel
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Investigation of the influences on children's active free-play

open access: yes, 2007
This research examined the influences on children's (6-12 years) active free-play. The findings suggest that there are a number of strategies that focus on individual, social and physical environmental factors that have the potential to be successful in ...
Jenny. Veitch (13785394)
core  

Active Play Every Day

open access: yes, 2023
All forms of play are really important for young children, however, active play is the most appropriate form of physical activity. Being physically active at an early age lays the foundation for good health, learning, communication and confidence as ...

core  

The chromosome peripheral proteins play an active role in chromosome dynamics

open access: yesBiomolecular Concepts, 2010
The chromosome periphery is a chromosomal structure that covers the surface of mitotic chromosomes. The structure and function of the chromosome periphery has been poorly understood since its first description in 1882.
Matsunaga Sachihiro, Fukui Kiichi
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

open access: yesFEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda   +2 more
wiley   +1 more source

Enriching students' oral language through active play. [PDF]

open access: yes, 2013
The purpose of this Master’s Thesis Project was to identify the relationship between active play and oral language development and create the Professional Development Project: ENRICHING STUDENTS' ORAL LANGUAGE DEVELOPMENT THROUGH ACTIVE PLAY.
Beringer, Kristine M.
core  

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