Results 71 to 80 of about 7,204,380 (286)

Muscle Activation during Exergame Playing [PDF]

, 2016
Exergames may provide low-cost solutions for playing, training and rehabilitation. Exergame user research, studies the interaction between an exergame and users, in order to provide feedback for game developers and safe and meaningful game play. Detailed evaluations and a coding system based on muscle activation levels are necessary to characterize ...
Soltani, Pooya, Vilas-Boas, João Paulo
openaire   +3 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Physical play - How do we inspire and motivate young children to be physically active through play? An international analysis of twelve countries’ national early years curriculum policies and practices for physical activity and physical play [PDF]

, 2023
Lifelong movement and physical activity (PA) patterns develop during early childhood. Therefore, educators (teachers and practitioners) in early childhood education and care (ECEC) should provide opportunities to support children’s play, PA, and movement
Vinci D., Vidoni C., D’Hondt E., Soini A., McCaffrey P., Sollerhed A-C, Tortella P., Coulter M., De Martelaer K., Hall N., Dong J., Jerebine A., McNally S., O’Keeffe C., Hernández-Martinez A., Howells, K., Coppens E., Wirth C., Sääkslahti A., Sienaert H., Costa A.M., Cools W., Urtel M.   +22 more
core  

The Case for Play Sufficiency in Schools: A rapid review of evidence on the role and influence of play in and beyond schools

This rapid review brings together recent research, grey literature, lived experience and practice examples to examine play in and around UK schools today.
Russell, Wendy K, Barclay, Mike, Play England, Youth Sport Trust   +3 more
core   +2 more sources

Effect of major school playground reconstruction on physical activity and sedentary behaviour: Camden active spaces

BMC Public Health, 2017
Background The physical school environment is a promising setting to increase children’s physical activity although robust evidence is sparse. We examined the effects of major playground reconstruction on physical activity and sedentary time in primary ...
Mark Hamer, Daniel Aggio, Georgina Knock, Courtney Kipps, Aparna Shankar, Lee Smith   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Splitting and Merging for Active Contours: Plug-and-Play

Mathematics
This study tackles the challenge of splitting and merging in parametric active contours or snakes. The proposed method comprises three stages: (1) fully 4-connected interpolation, (2) snake splitting, and (3) snakes merging.
Mojtaba Lashgari, Abhirup Banerjee, Hossein Rabbani   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Article 31 Action Pack Children's Rights and Children's Play : Resources for Action to Implement Article 31 of the United Nations Convention on the Rights of the Child [PDF]

, 2021
The right rest and leisure, to engage in play is usually missing from any discussions of children's rights. It is all too easy to fall into the trap of thinking only of those rights which are about protections; from poverty, from war and from abuse of ...
Shier, Harry, Hart, Roger, PLAY-TRAIN
core   +1 more source