Results 71 to 80 of about 442,906 (262)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

REDUCTION OF ACTIVE POWER LOSS BY IMPROVED FROG LEAPING ALGORITHM

International Journal of Research -GRANTHAALAYAH, 2017
This paper presents Improved Frog Leaping (IFL) algorithm for solving optimal reactive power problem.  Comprehensive exploration capability of Particle Swarm Optimization (PSO) and   good local search ability of Frog Leaping Algorithm (FLA) has been hybridized to solve the reactive power problem and it overcomes the shortcomings of premature ...
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

ACTIVE POWER LOSS REDUCTION BY AMPLIFIED ANT COLONY ALGORITHM

International Journal of Research -GRANTHAALAYAH, 2018
In this paper, Amplified Ant Colony (AAC) algorithm has been proposed for solving optimal reactive power problem. Mutation of Genetic algorithm (GA) is used in Ant Colony Algorithm (ACA) and the output of the GA is given as an input to the ACA. The proposed Amplified Ant Colony (AAC) algorithm has been tested on standard IEEE 118 & practical 191 ...
openaire   +3 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

REDUCTION OF ACTIVE POWER LOSS BY IMPROVED TABU SEARCH ALGORITHM

International Journal of Research -GRANTHAALAYAH, 2018
In this paper, an Improved Tabu Search (ITS) algorithm has been proposed to solve the optimal reactive power problem. In this work Tabu Search- has been hybridized with Simulated Annealing algorithm to solve the optimal reactive power problem. Hybridization of these two algorithms improves the exploration & exploitation capabilities during the ...
openaire   +3 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

ENHANCED SEEKER OPTIMIZATION ALGORITHM FOR REDUCTION OF ACTIVE POWER LOSS

International Journal of Research -GRANTHAALAYAH, 2017
This paper projects Enhanced Seeker Optimization (ESO) algorithm for solving optimal reactive power problem. Seeker optimization algorithm (SOA) models the deeds of human search population based on their memory, experience, uncertainty reasoning and communication with each other.
openaire   +3 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Total Fuel Cost, Power Loss, and Voltage Deviation Reduction for Power Systems with Optimal Placement and Operation of FACTS and Renewable Power Sources

Applied Sciences
The paper finds optimal power flows and optimal placement of wind power plants (WPPs), static var compensators (SVCs), and thyristor-controlled series capacitors (TCSCs) in the IEEE 30-bus transmission power network by applying three high-performance ...
Tuan Anh Nguyen, Le Chi Kien, Minh Quan Duong, Tan Minh Phan, Thang Trung Nguyen   +4 more
doaj   +1 more source