Results 111 to 120 of about 469,057 (262)

Nonrigid active shape model-based registration framework for motion correction of cardiac T₁ mapping. [PDF]

Magn Reson Med, 2018
El-Rewaidy H, Nezafat M, Jang J, Nakamori S, Fahmy AS, Nezafat R.   +5 more
europepmc   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Glassy dynamics in active epithelia emerge from an interplay of mechanochemical feedback and crowding

Nature Communications
Glassy dynamics in epithelial tissues remain a subject of debate, as theory predicts its emergence only at unrealistically low cellular activity, yet experimental studies have shown glassy dynamics at physiologically active conditions.
Sindhu Muthukrishnan, Phanindra Dewan, Tanishq Tejaswi, Michelle B. Sebastian, Tanya Chhabra, Soumyadeep Mondal, Soumitra Kolya, Sumantra Sarkar, Medhavi Vishwakarma   +8 more
doaj   +1 more source

Robust x-ray image segmentation by spectral clustering and active shape model. [PDF]

J Med Imaging (Bellingham), 2016
Wu J, Mahfouz MR.
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A medical imaging analysis system for trigger finger using an adaptive texture-based active shape model (ATASM) in ultrasound images. [PDF]

PLoS One, 2017
Chuang BI, Kuo LC, Yang TH, Su FC, Jou IM, Lin WJ, Sun YN.   +6 more
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Validation of an active shape model-based semi-automated segmentation algorithm for the analysis of thigh muscle and adipose tissue cross-sectional areas. [PDF]

MAGMA, 2017
Kemnitz J, Eckstein F, Culvenor AG, Ruhdorfer A, Dannhauer T, Ring-Dimitriou S, Sänger AM, Wirth W.   +7 more
europepmc   +1 more source