Results 31 to 40 of about 376,531 (312)

An example of International Drug Politics : The Development and Distribution of Substance Prevention Programs directed at Adolescents

, 2007
Many substance use prevention programs directed at adolescents exist that have been developed by researchers in the United States and are intended to be used in school settings.
Lilja, John, Hamilton, D, Larsson, Sam,, Giota, J   +3 more
core   +1 more source

Chemsex, HIV, and Psychiatric Diagnosis in Gay or Bisexual Men in Hong Kong

, 2023
Background: Psychotropic substance use, for chemsex in particular, is common in gay or bisexual men (GBM) with HIV infection. This case-control study examined the association between Axis I psychiatric disorders and active psychotropic substance use, and
Lee, KCK, Wong, BCK, Chung, AKK
core   +1 more source

Cytochalasin H enhances sensitivity to gefitinib in non-small-cell lung cancer cells through inhibiting EGFR activation and PD-L1 expression

Scientific Reports
In our previous study, we have isolated cytochalasin H (CyH) from endophytic fungus derived from mangrove plant and found that CyH inhibited the proliferation of non-small cell lung cancer (NSCLC) cells.
Guihong Zhang, Jiao Liu, Sanzhong Li, Tianyu Wang, Li Chen, Huan Li, Qingkai Ding, Xiangyong Li, Shaoping Zhu, Xudong Tang   +9 more
doaj   +1 more source

Novel benzamido derivatives as PTP1B inhibitors with anti-hyperglycemic and lipid-lowering efficacy

Acta Pharmaceutica Sinica B, 2018
Based on a non-competitive and selective PTP1B inhibitor reported by us previously, thirty-nine benzamido derivatives were designed and synthesized as novel PTP1B inhibitors.
Yanbo Tang, Xiaolin Zhang, Zheng Chen, Wenwen Yin, Guanglei Nan, Jinying Tian, Fei Ye, Zhiyan Xiao   +7 more
doaj   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Discovery of Novel Metalloenzyme Inhibitors Based on Property Characterization: Strategy and Application for HDAC1 Inhibitors

Molecules
Metalloenzymes are ubiquitously present in the human body and are relevant to a variety of diseases. However, the development of metalloenzyme inhibitors is limited by low specificity and poor drug-likeness associated with metal-binding fragments (MBFs).
Lu Zhang, Yajun Yang, Ying Yang, Zhiyan Xiao   +3 more
doaj   +1 more source

Separation of Alkyne Enantiomers by Chiral Column HPLC Analysis of Their Cobalt-Complexes

Molecules, 2017
Separation of the enantiomers of new chiral alkynes in strategic syntheses and bioorthogonal studies is always problematic. The chiral column high-performance liquid chromatography (HPLC) method in general could not be directly used to resolve such ...
Qiaoyun Liu, Jing Wang, Junfei Li, Xiaolei Wang, Shichao Lu, Xuan Li, Yaling Gong, Shu Xu   +7 more
doaj   +1 more source

Dynamic Changes and Correlation Analysis of Polysaccharide Content and Color Parameters in Glycyrrhiza Stems and Leaves during Fermentation

Fermentation, 2023
Fermentation can increase the concentration of active ingredients and improve the effectiveness of Chinese herbal medicine. The purpose of this study was to investigate the effect of solid-state fermentation (SSF) on the polysaccharide content and color ...
Juan Du, Yifeng Song, Xia Li, Na Liu, Xiaoping An, Jingwei Qi   +5 more
doaj   +1 more source

Nanotechnology of surface active substances.

Nanotechnologies in Construction: A Scientific Internet-Journal, 2018
To solve the problems of concrete quality and ecology the Russian science has been efficiently using wastes of chemical, metallurgical, biomedical and food production in construction for 70 years at the same time improving environment. The beginning of the ХХI century was marked by the appearance of the term «nanotechnology».
openaire   +2 more sources

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source