Results 31 to 40 of about 3,879,639 (303)

Discovery of Novel Metalloenzyme Inhibitors Based on Property Characterization: Strategy and Application for HDAC1 Inhibitors

Molecules
Metalloenzymes are ubiquitously present in the human body and are relevant to a variety of diseases. However, the development of metalloenzyme inhibitors is limited by low specificity and poor drug-likeness associated with metal-binding fragments (MBFs).
Lu Zhang, Yajun Yang, Ying Yang, Zhiyan Xiao   +3 more
doaj   +1 more source

Separation of Alkyne Enantiomers by Chiral Column HPLC Analysis of Their Cobalt-Complexes

Molecules, 2017
Separation of the enantiomers of new chiral alkynes in strategic syntheses and bioorthogonal studies is always problematic. The chiral column high-performance liquid chromatography (HPLC) method in general could not be directly used to resolve such ...
Qiaoyun Liu, Jing Wang, Junfei Li, Xiaolei Wang, Shichao Lu, Xuan Li, Yaling Gong, Shu Xu   +7 more
doaj   +1 more source

Recent and active problematic substance use among primary care patients: Results from the alcohol, smoking, and substance involvement screening test in a multisite study

, 2021
Background: Primary care settings provide salient opportunities for identifying patients with problematic substance use and addressing unmet treatment need.
Li-Tzy Wu, Greenblatt, Lawrence H, Wu, Li-Tzy, Lawrence H. Greenblatt, John, William S, William S. John, Zhu, He, He Zhu   +7 more
core   +1 more source

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan, Mariah Wright‐Nadkarni, Mohamed S. Abdelbaki, Girish Dhall   +3 more
wiley   +1 more source

Thermal proteome profiling reveals fructose-1,6-bisphosphate as a phosphate donor to activate phosphoglycerate mutase 1

Nature Communications
Deep understanding of sugar metabolite-protein interactions should provide implications on sugar metabolic reprogramming in human physiopathology. Although tremendous efforts have been made for determining individual event, global profiling of such ...
Yanling Zhang, Yafei Cao, Xia Wu, Zhenghui Chen, Bowen Chen, Anhui Wang, Yanshen Guo, Wei Chen, Ruolan Xue, Zihua Liu, Yuanpei Li, Tian Li, Ruiqin Cheng, Ning Zhou, Jing Li, Yuan Liu, Xiaohui Zhao, Huixin Luo, Ming Xu, Houhua Li, Yiqun Geng   +20 more
doaj   +1 more source

Dynamic Changes and Correlation Analysis of Polysaccharide Content and Color Parameters in Glycyrrhiza Stems and Leaves during Fermentation

Fermentation, 2023
Fermentation can increase the concentration of active ingredients and improve the effectiveness of Chinese herbal medicine. The purpose of this study was to investigate the effect of solid-state fermentation (SSF) on the polysaccharide content and color ...
Juan Du, Yifeng Song, Xia Li, Na Liu, Xiaoping An, Jingwei Qi   +5 more
doaj   +1 more source

Provider and Parent Perspectives on Prioritizing the “Asking and Monitoring” Pediatric Cancer Psychosocial Standards of Care

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The Standards for Psychosocial Care for Children with Cancer and Their Families (“Standards”) are evidence‐based guidelines for psychosocial care in pediatric oncology. Care related to the three “Asking and Monitoring” Standards—Assessment of Psychosocial Needs, Assessment of Financial Needs, and Monitoring Neurocognitive Problems ...
Julia B. Tager, Natalie Koskela‐Staples, Emily M. Pariseau, Michele Scialla, Kimberly Buff, Lori Wiener, Victoria Sardi Brown, Anne E. Kazak, Kimberly S. Canter   +8 more
wiley   +1 more source

An Efficient Synthesis of Aryl-Substituted Pyrroles by the Suzuki–Miyaura Coupling Reaction of SEM-Protected Pyrroles

Molecules, 2019
An efficient arylation of SEM-protected pyrroles by the Suzuki–Miyaura coupling reaction has been developed. The reaction can be carried out under mild conditions to provide aryl-substituted pyrroles in moderate to excellent yields.
Keli Cui, Meng Gao, Hongyi Zhao, Dongfeng Zhang, Hong Yan, Haihong Huang   +5 more
doaj   +1 more source

Nanotechnology of surface active substances.

Nanotechnologies in Construction: A Scientific Internet-Journal, 2018
To solve the problems of concrete quality and ecology the Russian science has been efficiently using wastes of chemical, metallurgical, biomedical and food production in construction for 70 years at the same time improving environment. The beginning of the ХХI century was marked by the appearance of the term «nanotechnology».
openaire   +2 more sources

Hazardous Substances and Activities

, 2021
Abstract This chapter analyses the enormous scope of international instruments addressing hazardous substances and activities by assessing both the regulatory junctures and the specific strategies that governments rely upon to reduce risk.
Wirth, David A., Sachs, Noah M.
openaire   +1 more source