Results 41 to 50 of about 404,156 (246)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

The Influence of Semi-Active Suspension Adjustment on Vehicle Body Pitch Oscillations

Transport and Telecommunication, 2019
In this paper the relation between semi-active suspension characteristics and vertical oscillations of the vehicle body on road roughness is analysed. During experimental tests, the damping of semi-active suspension was changed while measuring vehicle's ...
Surblys Vytenis, Žuraulis Vidas, Sokolovskij Edgar   +2 more
doaj   +1 more source

Implementations of Full State Feedback Robust Control Designs for Mechanical Systems Using Only Positions or Velocities Output Feedback

IEEE Access, 2022
This paper proposes a new design and practical implementation of a robust ${\mathcal H}_{\infty }$ control applied to some mechanical systems considering in the controller design full access to the state variables and in the equivalent controller ...
Lucas M. Esteves, Rodrigo Cardim, Marcelo C. M. Teixeira, Diogo R. De Oliveira, Jean M. De S. Ribeiro, Edvaldo Assuncao, Hyago R. M. Silva   +6 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Nonlinear Time-Delay Suspension Adaptive Neural Network Active Control

Abstract and Applied Analysis, 2014
Considering the time-delay in control input channel and the nonlinear spring stiffness characteristics of suspension, a quarter-vehicle magneto rheological active suspension nonlinear model with time-delay is established in this paper.
Yue Zhu, Sihong Zhu
doaj   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Performance Improvement of Active MacPherson Suspension Using a Pneumatic Muscle and an Intelligent Vibration Compensator

IEEE Access, 2020
This paper presents an intelligent control strategy for an active MacPherson suspension driven by a pneumatic muscle (PM) actuated system and evaluates its improved control performance on a self-developed test-rig.
Lian-Wang Lee, Hsin-Han Chiang, I-Hsum Li   +2 more
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Control of the Active Suspension for In-Wheel Motor

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2013
This study raises a new electric wheel with active control of suspension for in-wheel motor. Proceeding from the reality, we made a simulation analysis on these four models: a sample car with no motor, a motor with fixed joint, and active/inactive ...
Ying MA, Zhaoxiang DENG, Dan XIE
doaj   +1 more source