Active Targeting of the Nucleus Using Nonpeptidic Boronate Tags.
Journal of the American Chemical Society, 2017 Active intracellular transport is a central mechanism in cell biology, directed by a limited set of naturally occurring signaling peptides. Here, we report the first nonpeptide moiety that recruits intracellular transport machinery for nuclear targeting.
Rui Tang +6 more
semanticscholar +1 more source
Active diffusion positions the nucleus in mouse oocytes
Nature Cell Biology, 2015 In somatic cells, the position of the cell centroid is dictated by the centrosome. The centrosome is instrumental in nucleus positioning, the two structures being physically connected.
M. Almonacid +7 more
semanticscholar +1 more source
Protoparvovirus Knocking at the Nuclear Door
Viruses, 2017 Protoparvoviruses target the nucleus due to their dependence on the cellular reproduction machinery during the replication and expression of their single-stranded DNA genome.
Elina Mäntylä +2 more
doaj +1 more source
Nanoscale protein diffusion by STED-based pair correlation analysis. [PDF]
PLoS ONE, 2014 We describe for the first time the combination between cross-pair correlation function analysis (pair correlation analysis or pCF) and stimulated emission depletion (STED) to obtain diffusion maps at spatial resolution below the optical diffraction limit
Paolo Bianchini +4 more
doaj +1 more source
A possible mechanism for self coordination of bi-directional traffic across nuclear pores [PDF]
Phys. Biol. 5, 036001 (2008), 2008 Nuclear pore complexes are constantly confronted by large fluxes of macromolecules and macromolecular complexes that need to get into and out of the nucleus. Such bi-directional traffic occurring in a narrow channel can easily lead to jamming. How then is passage between the nucleus and cytoplasm maintained under the varying conditions that arise ...
arxiv +1 more source
Spatial Organization of the Cytoskeleton enhances Cargo Delivery to Specific Target Areas on the Plasma Membrane of Spherical Cells [PDF]
, 2016 Intracellular transport is vital for the proper functioning and survival of a cell. Cargo (proteins, vesicles, organelles, etc.) is transferred from its place of creation to its target locations via molecular motor assisted transport along cytoskeletal ...
Hafner, Anne E., Rieger, Heiko
core +2 more sources
Quantifying intermittent transport in cell cytoplasm [PDF]
, 2008 Active cellular transport is a fundamental mechanism for protein and vesicle delivery, cell cycle and molecular degradation. Viruses can hijack the transport system and use it to reach the nucleus. Most transport processes consist of intermittent dynamics, where the motion of a particle, such as a virus, alternates between pure Brownian and directed ...
arxiv +1 more source
The influence of nucleus mechanics in modelling adhesion-independent cell migration in structured and confined environments [PDF]
arXiv, 2022 Recent biological experiments have shown that certain types of cells are able to move in structured and confined environment even without the activation of focal adhesion. Focusing on this particular phenomenon and based on previous works, we derive a novel two-dimensional mechanical model, which relies on the following physical ingredients: the ...
arxiv
Energetic constraints on filament mediated cell polarization [PDF]
, 2021 Cell polarization underlies many cellular processes, such as differentiation, migration, and budding. Many living cells, such as budding yeast and fission yeast, use cytoskeletal structures to actively transport proteins to one location on the membrane and create a high density spot of membrane-bound proteins.
arxiv +1 more source
Roles of Cross-Membrane Transport and Signaling in the Maintenance of Cellular Homeostasis [PDF]
, 2016 Organelles allow specialized functions within cells to be localized, contained and independently regulated. This separation is oftentimes achieved by selectively permeable membranes, which enable control of molecular transport, signaling between ...
Inchul Cho, Joe Swift, Mark R. Jackson
core +2 more sources