Results 61 to 70 of about 9,999,055 (259)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Rhinovirus 3C protease can localize in the nucleus and alter active and passive nucleocytoplasmic transport

, 2009
The degradation of nuclear pore components and disruption of nucleocytoplasmic trafficking during rhinovirus infection have been attributed to viral 2A protease.
D. Li, B. Jordan, R. Ghildyal, P. G. Bardin, Bardin, Phillip G, Gern, James E, H. Dagher, J. E. Gern, Ghildyal, Reena, Li, Dongsheng, Jans, David, Ghildyal, Reena; id_orcid, Jordan, Benjamin, D. A. Jans, Bardin, Philip, Gern, James, Dagher, Hayat, Jans, David A, Dongsheng, Li   +18 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

REGULATION OF ARABIDOPSIS GDH2 NUCLEAR GENE EXPRESSION DEPENDS ON FUNCTIONAL STATE OF MITOCHONDRIA AND CHLOROPLASTS [PDF]

Journal of Stress Physiology & Biochemistry, 2012
The results of recent studies indicate that expression of some plant nuclear genes depends on functional state of mitochondria and chloroplasts.
Garnik E.Yu., V.I. Tarasenko, V.N. Shmakov, V.I. Bel'kov, Yu.M. Konstantinov   +4 more
doaj  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Antiestrogenic Activity of the Xi-Huang Formula for Breast Cancer by Targeting the Estrogen Receptor α

Cellular Physiology and Biochemistry, 2018
Background/Aims: The Xi-Huang (XH) formula has been used for breast cancer treatment in traditional Chinese medicine (TCM) since 1740. In this study, we show that, XH extract could suppress the growth of breast cancer cells in vitro and in vivo, and that
Jian Hao, Ziqi Jin, Hongxu Zhu, Xiaohui Liu, Yu Mao, Xue Yang, Li Gao, Dan Liu, Dan Chen, Xiongzhi Wu   +9 more
doaj   +1 more source

Functional characterization of nuclear localization and export signals in hepatitis C virus proteins and their role in the membranous web. [PDF]

PLoS ONE, 2014
The hepatitis C virus (HCV) is a positive strand RNA virus of the Flavivirus family that replicates in the cytoplasm of infected hepatocytes. Previously, several nuclear localization signals (NLS) and nuclear export signals (NES) have been identified in ...
Aviad Levin, Christopher J Neufeldt, Daniel Pang, Kristen Wilson, Darci Loewen-Dobler, Michael A Joyce, Richard W Wozniak, D Lorne J Tyrrell   +7 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source