Results 181 to 190 of about 158,807,029 (257)

Impact of Hemoglobin Improvement on Survival in Patients With Myelofibrosis and Anemia Treated With Momelotinib in the SIMPLIFY‐1 and MOMENTUM Trials

European Journal of Haematology, Volume 117, Issue 5, Page 1265-1274, November 2026.
In this post hoc analysis of the phase 3 SIMPLIFY‐1 and MOMENTUM trials, the number of patients with baseline hemoglobin < 10 g/dL who achieved hemoglobin ≥ 10 g/dL by week 24 with momelotinib, as well as the time to achievement, were evaluated. Patients who were JAK inhibitor naive and/or had moderate anemia were more likely and faster to achieve this
Francesca Palandri, Casey O'Connell, Pankit Vachhani, Donal P. McLornan, Steffen Koschmieder, Juan Carlos Hernandez‐Boluda, Kazuya Shimoda, Shiyuan Zhang, Catherine Ellis, Jessica Lim, Jasmine Sahni, Vikas Gupta   +11 more
wiley   +1 more source

Biochemical profiling and symptomatology of androgen deficiency in males with cluster headache: A prospective case–control study

Headache: The Journal of Head and Face Pain, Volume 66, Issue 10, Page 2337-2349, November/December 2026.
Abstract Objectives/Background Cluster headache (CH) has historically been considered a male‐dominated disorder, suggesting a role for androgens in its pathophysiology. We aimed to evaluate hormone profiles and symptoms of androgen deficiency in CH.
Willemijn C. Naber, Roemer B. Brandt, Mariël Leon Morales‐Grooters, Ronald van der Wal, Sjoerd A. A. van den Berg, Jelle J. Goeman, Antoinette Maassen van den Brink, Rolf Fronczek   +7 more
wiley   +1 more source

Activin-A causes Hepatic stellate cell activation via the induction of TNFα and TGFβ in Kupffer cells.

Biochimica et Biophysica Acta - Molecular Basis of Disease, 2018
Foteini Kiagiadaki, M. Kampa, A. Voumvouraki, E. Castanas, E. Kouroumalis, G. Notas   +5 more
semanticscholar   +1 more source

Lipoprotein(a), Endothelial Dysfunction and Cardiovascular Disease

Journal of Cellular and Molecular Medicine, Volume 30, Issue 21, November 2026.
ABSTRACT Lipoprotein(a) (Lp(a)) is a particle similar to low‐density lipoprotein cholesterol and is associated with apolipoprotein (A). High Lp(a) levels are a genetic, independent risk factor for atherosclerotic cardiovascular disease (ASCVD). Endothelial cells, which form the continuous lining of the cardiovascular system, are crucial for vascular ...
Xianghui Zhou, Xiyuan Fang, Xin Zhou, Zhao Zhang, Yu Hu, Zhipeng Cheng   +5 more
wiley   +1 more source

Human Bone Morphogenetic Protein‐3 Mature Ligand Is Larger Than Recorded Indicating Earlier Publications Are Flawed

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
BMP‐3 is synthesized as a proprotein that is cleaved by furin/proprotein convertases (PC) to release the biologically active mature ligand. Although never experimentally verified, the BMP‐3 ligand is recorded as C‐terminal Q363‐R472 (110 amino acids) approximately 16 kDa.
David E. Phelan, Caitriona Scaife, Emma R. Dorris, John Russell, Madeline Murphy   +4 more
wiley   +1 more source

Activin-A co-opts IRF4 and AhR signaling to induce human regulatory T cells that restrain asthmatic responses

Proceedings of the National Academy of Sciences of the United States of America, 2017
Sofia Tousa, M. Semitekolou, I. Morianos, A. Banos, Aikaterini I Trochoutsou, Tess M. Brodie, Nikolaos Poulos, K. Samitas, Maria Kapasa, Dimitris Konstantopoulos, G. Paraskevopoulos, M. Gaga, C. Hawrylowicz, F. Sallusto, G. Xanthou   +14 more
semanticscholar   +1 more source

Activin A programs the differentiation of human TFH cells

Nature Immunology, 2016
Michela Locci, Jennifer E. Wu, Fortuna Arumemi, Z. Mikulski, C. Dahlberg, Andrew T. Miller, S. Crotty   +6 more
semanticscholar   +1 more source

NFкB pathway suppression as a key driver of pacritinib response in high‐risk myelofibrosis

British Journal of Haematology, Volume 209, Issue 5, Page 2331-2334, November 2026.
R. Van Dijck, M. ter Borg, B. van der Holt, A. E. C. Broers, M. D. Hazenberg, J. J. Cornelissen, N. P. M. Schaap, E. de Pater, P. A. W. te Boekhorst   +8 more
wiley   +1 more source

Betacellulin and Activin A Coordinately

, 2014
Rat pancreatic AR42J cells possess exocrine and neuroendocrine properties. Activin A induces morphological changes and converts them into neuron-like cells. In activin-treated cells, mRNA for pancreatic polypeptide (PP) but not that for either insulin or
Convert Amylase-secreting Pancreatic, Insulin-secreting Cells, Masaharu Seno, Hidenori Yamada, Itaru Kojima, Arj Cells   +5 more
core  

Healthy Participant Versus Patient Selection for Clinical Pharmacology Studies in Small‐Molecule Oncology Drug Development

Clinical and Translational Science, Volume 19, Issue 11, November 2026.
Paridhi Gupta, Zheyi Hu, Li Zhu, Lora Hamuro   +3 more
wiley   +1 more source