Results 1 to 10 of about 9,676 (180)

Follistatin and follistatin-like 3 in metabolic disorders

Prostaglandins and Other Lipid Mediators, 2023
Follistatin (FST) is a glycoprotein which main role is antagonizing activity of transforming growth factor β superfamily members. Folistatin-related proteins such as follistatin-like 3 (FSTL3) also reveal these properties. The exact function of them has still not been established, but it can be bound to the pathogenesis of metabolic disorders.
Andrzej Pawlik
exaly   +3 more sources

Deletion of fibro-adipogenic progenitors-specific follistatin impairs muscle function and accelerates skeletal muscle atrophy in obese mice [PDF]

Molecular Medicine
Background Follistatin is a potent regulator of various TGF-β superfamily members, including myostatin (MSTN) and activin A. Previous studies have shown that follistatin is crucial in enhancing myogenesis during acute muscle injury.
Muhammad Rahil Aslam, Muhammad Bilal, Allah Nawaz, Tomonobu Kado, Shinya Abe, Nguyen Quynh Phuong, Memoona, Sana Khalid, Le Duc Anh, Ayumi Nishimura, Yoshiyuki Watanabe, Yoshiko Igarashi, Naeem Iqbal, Maki Yokoyama, Yasuhiro Onogi, Kennichi Hirabayashi, Hiroyuki  Miwa, Takumi Era, Martin M. Matzuk, Seiji Yamamoto, Koichi Ikuta, Isao Usui, Kohta Kobayashi, Toshihiko Satake, Masaru Kato, Shiho Fujisaka, Kazuyuki Tobe   +26 more
doaj   +2 more sources

Higher serum follistatin levels are associated with increased vascular calcification in haemodialysis patients [PDF]

Frontiers in Endocrinology
IntroductionFollistatin is a secreted protein whose main role is antagonizing the activity of transforming growth factor β (TGF-β) superfamily members.
Conghui Liu, Conghui Liu, Aihua Zhang, Zhongxin Li   +3 more
doaj   +2 more sources

Deranged expression of follistatin and follistatin-like protein in women with ovarian endometriosis

Fertility and Sterility, 2007
To evaluate the messenger RNA (mRNA) expression and peptide localization of follistatin and follistatin-like protein (FLRG) in ovarian endometriosis, compared to healthy human endometrium.Samples of ovarian endometriotic and healthy endometrial tissues were processed by semiquantitative reverse transcriptase-polymerase chain reaction and ...
M C Ferreira, Michela Torricelli, Felice Petraglia   +2 more
exaly   +7 more sources

Tubule-Derived Follistatin Is Increased in the Urine of Rats with Renal Ischemia and Reflects the Severity of Acute Tubular Damage

Cells, 2023
Activin A, a member of the TGF-beta superfamily, is a negative regulator of tubular regeneration after renal ischemia. Activin action is controlled by an endogenous antagonist, follistatin.
Izumi Nagayama, Kaori Takayanagi, Hajime Hasegawa, Akito Maeshima   +3 more
doaj   +1 more source

Follistatin Is Associated with Bone Mineral Density in Lean Adolescent Girls with Increased Physical Activity

Children, 2023
Follistatin is a member of the activin–follistatin–inhibin hormonal system and is proposed to affect bone metabolism. However, data regarding the effect of follistatin on bone are relatively scarce and contradictory in humans.
Jaak Jürimäe, Liina Remmel, Anna-Liisa Tamm, Priit Purge, Katre Maasalu, Vallo Tillmann   +5 more
doaj   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Decreased Follistatin Levels as a Risk of Acute Sarcopenia Marker in Elderly

MCBS (Molecular and Cellular Biomedical Sciences), 2023
Background: Acute sarcopenia is an acute muscle loss that has been associated to the frailty and vulnerability of the elderly. Follistatin has been known as a significant marker for sarcopenia, however, studies of follistatin in humans have shown varying
I Gusti Putu Suka Aryana, I Made Arya Winangun   +1 more
doaj   +1 more source

Pre- and Peri-/Post-Compaction Follistatin Treatment Increases In Vitro Production of Cattle Embryos. [PDF]

PLoS ONE, 2017
Our previous studies demonstrated that maternal (oocyte derived) follistatin (FST) expression is positively associated with bovine oocyte competence and exogenous follistatin treatment during the pre-compaction period of development (d 1-3 post ...
Guo Zhenhua, Sandeep K Rajput, Joseph K Folger, Liu Di, Jason G Knott, George W Smith   +5 more
doaj   +1 more source

The Role of Follistatin Domains in Follistatin Biological Action [PDF]

Molecular Endocrinology, 2004
Follistatin (FS) is an important regulator of pituitary FSH secretion through its potent ability to bind and bioneutralize activin. It also represents a prototype for binding proteins that control bioavailability of other TGFbeta-related growth factors such as the bone morphogenetic proteins.
Henry T, Keutmann, Alan L, Schneyer, Yisrael, Sidis   +2 more
openaire   +2 more sources