Results 1 to 10 of about 11,005 (174)

Tissue absence initiates regeneration through Follistatin-mediated inhibition of Activin signaling [PDF]

eLife, 2013
Regeneration is widespread, but mechanisms that activate regeneration remain mysterious. Planarians are capable of whole-body regeneration and mount distinct molecular responses to wounds that result in tissue absence and those that do not.
Michael A Gaviño, Danielle Wenemoser, Irving E Wang, Peter W Reddien   +3 more
doaj   +6 more sources

Follistatin and follistatin-like 3 in metabolic disorders

Prostaglandins and Other Lipid Mediators, 2023
Follistatin (FST) is a glycoprotein which main role is antagonizing activity of transforming growth factor β superfamily members. Folistatin-related proteins such as follistatin-like 3 (FSTL3) also reveal these properties. The exact function of them has still not been established, but it can be bound to the pathogenesis of metabolic disorders.
Weronika Bielka, Andrzej Pawlik
exaly   +3 more sources

The Mechanical Stimulation of Myotubes Counteracts the Effects of Tumor-Derived Factors Through the Modulation of the Activin/Follistatin Ratio [PDF]

Frontiers in Physiology, 2019
Activin negatively affects muscle fibers and progenitor cells in aging (sarcopenia) and in chronic diseases characterized by severe muscle wasting (cachexia). High circulating activin levels predict poor survival in cancer patients. However, the relative
Alexandra Baccam, Alexandra Baccam, Alexandra Baccam, Alexandra Benoni-Sviercovich, Alexandra Benoni-Sviercovich, Alexandra Benoni-Sviercovich, Marco Rocchi, Viviana Moresi, Viviana Moresi, Marilia Seelaender, Zhenlin Li, Sergio Adamo, Sergio Adamo, Zhigang Xue, Dario Coletti, Dario Coletti, Dario Coletti   +16 more
doaj   +4 more sources

Deranged expression of follistatin and follistatin-like protein in women with ovarian endometriosis

Fertility and Sterility, 2007
To evaluate the messenger RNA (mRNA) expression and peptide localization of follistatin and follistatin-like protein (FLRG) in ovarian endometriosis, compared to healthy human endometrium.Samples of ovarian endometriotic and healthy endometrial tissues were processed by semiquantitative reverse transcriptase-polymerase chain reaction and ...
Marcus Castro Ferreira, Michela Torricelli, Fernando M Reis   +2 more
exaly   +7 more sources

Differential expression of follistatin and FLRG in human breast proliferative disorders [PDF]

BMC Cancer, 2009
Background Activins are growth factors acting on cell growth and differentiation. Activins are expressed in high grade breast tumors and they display an antiproliferative effect inducing G0/G1 cell cycle arrest in breast cancer cell lines.
Amaral Vania F, Grasso Giovanni, Muscettola Michela, Borges Lavinia E, Mencarelli Marzia, Ciarmela Pasquapina, Massai Lauretta, Couto Henrique L, Bloise Enrrico, Cassali Geovanni D, Petraglia Felice, Reis Fernando M   +11 more
doaj   +4 more sources

Exercise Induces a Marked Increase in Plasma Follistatin: Evidence That Follistatin Is a Contraction-Induced Hepatokine [PDF]

Endocrinology, 2011
Abstract Follistatin is a member of the TGF-β super family and inhibits the action of myostatin to regulate skeletal muscle growth. The regulation of follistatin during physical exercise is unclear but may be important because physical activity is a major intervention to prevent age-related sarcopenia.
Claus Brandt, Pernille Hojman, Martin Whitham   +2 more
exaly   +4 more sources

Tubule-Derived Follistatin Is Increased in the Urine of Rats with Renal Ischemia and Reflects the Severity of Acute Tubular Damage

Cells, 2023
Activin A, a member of the TGF-beta superfamily, is a negative regulator of tubular regeneration after renal ischemia. Activin action is controlled by an endogenous antagonist, follistatin.
Izumi Nagayama, Kaori Takayanagi, Hajime Hasegawa, Akito Maeshima   +3 more
doaj   +1 more source

Follistatin Is Associated with Bone Mineral Density in Lean Adolescent Girls with Increased Physical Activity

Children, 2023
Follistatin is a member of the activin–follistatin–inhibin hormonal system and is proposed to affect bone metabolism. However, data regarding the effect of follistatin on bone are relatively scarce and contradictory in humans.
Jaak Jürimäe, Liina Remmel, Anna-Liisa Tamm, Priit Purge, Katre Maasalu, Vallo Tillmann   +5 more
doaj   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Decreased Follistatin Levels as a Risk of Acute Sarcopenia Marker in Elderly

MCBS (Molecular and Cellular Biomedical Sciences), 2023
Background: Acute sarcopenia is an acute muscle loss that has been associated to the frailty and vulnerability of the elderly. Follistatin has been known as a significant marker for sarcopenia, however, studies of follistatin in humans have shown varying
I Gusti Putu Suka Aryana, I Made Arya Winangun   +1 more
doaj   +1 more source