Results 11 to 20 of about 9,676 (180)

Elevated circulating follistatin associates with an increased risk of type 2 diabetes

Nature Communications, 2021
Follistatin promotes in type 2 diabetes (T2D) pathogenesis in model animals and is elevated in patients with T2D. Here the authors report that plasma follistatin associates with increased risk of incident T2D in two longitudinal cohorts, and show that ...
Chuanyan Wu, Yan Borné, Rui Gao, Maykel López Rodriguez, William C. Roell, Jonathan M. Wilson, Ajit Regmi, Cheng Luan, Dina Mansour Aly, Andreas Peter, Jürgen Machann, Harald Staiger, Andreas Fritsche, Andreas L. Birkenfeld, Rongya Tao, Robert Wagner, Mickaël Canouil, Mun-Gwan Hong, Jochen M. Schwenk, Emma Ahlqvist, Minna U. Kaikkonen, Peter Nilsson, Angela C. Shore, Faisel Khan, Andrea Natali, Olle Melander, Marju Orho-Melander, Jan Nilsson, Hans-Ulrich Häring, Erik Renström, Claes B. Wollheim, Gunnar Engström, Jianping Weng, Ewan R. Pearson, Paul W. Franks, Morris F. White, Kevin L. Duffin, Allan Arthur Vaag, Markku Laakso, Norbert Stefan, Leif Groop, Yang De Marinis   +41 more
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Circulating follistatin concentrations in adolescent PCOS: Divergent effects of randomized treatments

Frontiers in Endocrinology, 2023
PurposeFollistatin is a glycoprotein that represses members of the transforming growth factor-β superfamily including activin. Higher follistatin levels have been associated with an increased risk for type 2 diabetes and with polycystic ovary syndrome ...
Marta Díaz, Marta Díaz, Francis de Zegher, Lourdes Ibáñez, Lourdes Ibáñez   +4 more
doaj   +1 more source

Grass Carp Follisatin: Molecular Cloning, Functional Characterization, Dopamine D1 Regulation at Pituitary Level, and Implication in Growth Hormone Regulation

Frontiers in Endocrinology, 2017
Activin is involved in pituitary hormone regulation and its pituitary actions can be nullified by local production of its binding protein follistatin. In our recent study with grass carp, local release of growth hormone (GH) was shown to induce activin ...
Roger S. K. Fung, Bai Jin, Mulan He, Karen W. Y. Yuen, Anderson O. L. Wong   +4 more
doaj   +1 more source

Differential Biosynthesis and Intracellular Transport of Follistatin Isoforms and Follistatin-Like-3 [PDF]

Endocrinology, 2005
Follistatin (FST) and FST-like-3 (FSTL3) are structurally related proteins that bind and neutralize activin and closely related members of the TGFβ superfamily. Three FST isoforms (FST288, FST303, and FST315) are produced from the Fst gene that are primarily secreted proteins. FSTL3 is secreted, but is also observed within the nucleus of most cells. We
Seiichiro, Saito, Yisrael, Sidis, Abir, Mukherjee, Yin, Xia, Alan, Schneyer   +4 more
openaire   +2 more sources

The association of the serum levels of myostatin, follistatin, and interleukin-6 with sarcopenia, and their impacts on survival in patients with hepatocellular carcinoma [PDF]

Clinical and Molecular Hepatology, 2020
Background/Aims The role of serum myokine levels in sarcopenia and the outcome of hepatocellular carcinoma (HCC) patients are not clear. This study investigated the serum levels of myostatin, follistatin, and interleukin-6 (IL-6) in HCC patients and ...
Kanghyug Choi, Hee Yoon Jang, Joong Mo Ahn, Sung Ho Hwang, Jung Wha Chung, Yun Suk Choi, Jin-Wook Kim, Eun Sun Jang, Gwang Hyeon Choi, Sook-Hyang Jeong   +9 more
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Human Follistatin-Related Protein: A Structural Homologue of Follistatin with Nuclear Localization [PDF]

Endocrinology, 2001
Follistatin-related protein is a recently discovered glycoprotein that is highly homologous in both primary sequence and exon/intron domain structure to the activin-binding protein, follistatin. We explored their potential for functional redundancy by investigating the relative affinities and kinetics of their interactions with activin, bone ...
D V, Tortoriello, Y, Sidis, D A, Holtzman, W E, Holmes, A L, Schneyer   +4 more
openaire   +2 more sources

Follistatin supplementation induces changes in CDX2 CpG methylation and improves in vitro development of bovine SCNT preimplantation embryos

Reproductive Biology and Endocrinology, 2021
Caudal Type Homeobox 2 (CDX2) is a key regulator of trophectoderm formation and maintenance in preimplantation embryos. We previously demonstrated that supplementation of exogenous follistatin, during in vitro culture of bovine IVF embryos, upregulates ...
Mohamed Ashry, Chunyan Yang, Sandeep K. Rajput, Joseph K. Folger, Jason G. Knott, George W. Smith   +5 more
doaj   +1 more source

Follistatin and Follistatin Like‐3 Differentially Regulate Adiposity and Glucose Homeostasis [PDF]

Obesity, 2011
Transforming growth factor‐β superfamily ligands, including activin and myostatin, modulate body composition, islet function, and glucose homeostasis. Their bioactivity is controlled by the antagonists follistatin (FST) and FST like‐3 (FSTL3). The hypothesis tested was that FST and FSTL3 have distinct roles in regulating body composition, glucose ...
Melissa L, Brown, Lara, Bonomi, Nathan, Ungerleider, Jessica, Zina, Fuminori, Kimura, Abir, Mukherjee, Yisrael, Sidis, Alan, Schneyer   +7 more
openaire   +2 more sources

Follistatin Alleviates Synovitis and Articular Cartilage Degeneration Induced by Carrageenan

International Journal of Inflammation, 2014
Activins are proinflammatory cytokines which belong to the TGFβ superfamily. Follistatin is an extracellular decoy receptor for activins. Since both activins and follistatin are expressed in articular cartilage, we hypothesized that activin-follistatin ...
Jun Yamada, Kunikazu Tsuji, Kazumasa Miyatake, Yu Matsukura, Kahaer Abula, Makiko Inoue, Ichiro Sekiya, Takeshi Muneta   +7 more
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Cloning and sequence analysis of Paralichthys olivaceus Follistatin cDNA

浙江大学学报. 农业与生命科学版, 2007
To study the DNA sequence features of Follistatin gene in marine fish, Paralichthys olivaceus Follistatin cDNA was isolated and analyzed from Paralichthys olivaceus embryos 67 h after fertilization.
LIU Qing-hua, TAN Xun-gang, XU Yong-li, ZHANG Pei-jun, XU Peng   +4 more
doaj   +1 more source