Biomolecules, 2023 Myostatin (growth differentiation factor 8) is a member of the transforming growth factor-β superfamily. It is secreted mostly by skeletal muscles, although small amounts of myostatin are produced by the myocardium and the adipose tissue as well ...
Małgorzata Knapp +2 more
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Myostatin Orchestrates miR-124-Mediated Epigenetic Silencing of ITGB1 to Suppress Skeletal Muscle Growth [PDF]
BiomoleculesAlthough myostatin is a well-established inhibitor of myogenesis, its downstream mediators remain poorly characterized. This study identified integrin β1 (ITGB1), an integrin family member, as a novel mediator in myostatin signaling.
Qi Chen +8 more
doaj +2 more sources
Journal of Cachexia, Sarcopenia and Muscle, 2018 Background Myostatin is a negative regulator of muscle growth but the relationship between serum myostatin levels and muscle mass is unclear. This study investigated the association between serum myostatin levels and skeletal muscle mass among healthy ...
Liang-Kung Chen +2 more
exaly +2 more sources
A novel splice variant of the human MSTN gene encodes a myostatin‐specific myostatin inhibitor
Journal of Cachexia, Sarcopenia and Muscle, 2023 Background Myostatin, encoded by the MSTN gene comprising 3 exons, is a potent negative regulator of skeletal muscle growth. Although a variety of myostatin inhibitors have been invented for increasing muscle mass in muscle wasting diseases, no effective
Kazuhiro Maeta +3 more
doaj +1 more source
Myostatin is upregulated following stress in an Erk-dependent manner and negatively regulates cardiomyocyte growth in culture and in a mouse model. [PDF]
PLoS ONE, 2010 Myostatin is well established as a negative regulator of skeletal muscle growth, but its role in the heart is controversial. Our goal in this study was to characterize myostatin regulation following cardiomyocyte stress and to examine the role of ...
Lawrence T Bish +3 more
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Signals of Ezh2, Src, and Akt Involve in myostatin-Pax7 pathways regulating the myogenic fate determination during the sheep myoblast proliferation and differentiation. [PDF]
PLoS ONE, 2015 Myostatin and Pax7 have been well documented individually, however, the mechanism by which Myostatin regulates Pax7 is seldom reported. Here, based on muscle transcriptome analysis in Texel (Myostatin mutant) and Ujumqin (wild type) sheep across the five
Caihong Wei +9 more
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Systemic myostatin inhibition via liver-targeted gene transfer in normal and dystrophic mice. [PDF]
PLoS ONE, 2010 Myostatin inhibition is a promising therapeutic strategy to maintain muscle mass in a variety of disorders, including the muscular dystrophies, cachexia, and sarcopenia.
Kevin J Morine +5 more
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Regulation of Myostatin on the Growth and Development of Skeletal Muscle
Frontiers in Cell and Developmental Biology, 2021 Myostatin (MSTN), a member of the transforming growth factor-β superfamily, can negatively regulate the growth and development of skeletal muscle by autocrine or paracrine signaling.
Ming-Ming Chen +4 more
doaj +1 more source
BMC Nutrition, 2022 Background Elevated concentrations of myostatin inhibit muscle growth, function and strength. Myostatin is a mediator of sarcopenia and is associated with insulin resistance.
Cydne A. Perry +2 more
doaj +1 more source
Effect of myostatin depletion on weight gain, hyperglycemia, and hepatic steatosis during five months of high-fat feeding in mice. [PDF]
PLoS ONE, 2011 The marked hypermuscularity in mice with constitutive myostatin deficiency reduces fat accumulation and hyperglycemia induced by high-fat feeding, but it is unclear whether the smaller increase in muscle mass caused by postdevelopmental loss of myostatin
Kerri Burgess +4 more
doaj +1 more source