Results 1 to 10 of about 3,759,300 (312)

Regulation of the evolutionarily conserved muscle myofibrillar matrix by cell type dependent and independent mechanisms

Nature Communications, 2022
Recent work has shown that mammalian muscle cells are comprised of multiple branching sarcomeres, though how this connectivity is regulated has remained unknown.
Peter T. Ajayi, Prasanna Katti, Yingfan Zhang, T. Bradley Willingham, Ye Sun, Christopher K. E. Bleck, Brian Glancy   +6 more
doaj   +1 more source

The importance of TP53/p53 in regulating the mitophagy-lysosomal machinery in muscle following disuse

Autophagy Reports, 2022
Since being discovered in the late 1990s, TP53/TRP53/p53 has been a focal point of research, lauded for its role as a tumor-suppressor protein. Considerable attention has also been devoted to understanding how TP53 regulates metabolic programming of the ...
Jonathan M. Memme, Ashley N. Oliveira, David A. Hood   +2 more
doaj   +1 more source

Extraocular Muscle Imbalance and Outcomes of Scleral Buckling Surgery for Primary Rhegmatogenous Retinal Detachment [PDF]

, 2020
Objective: The objective was to study the muscle imbalance, restrictive motility in unlike gazes and the outcomes of the scleral buckling surgery for rhegmatogenous retinal detachment.
Kawish, A. B. (Ayesha), Nawaz, S. (Sadia), Tahir, Q. (Qandeel)   +2 more
core   +1 more source

Complementary NAD+ replacement strategies fail to functionally protect dystrophin-deficient muscle

Skeletal Muscle, 2020
Background Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disorder stemming from a loss of functional dystrophin. Current therapeutic options for DMD are limited, as small molecule modalities remain largely unable to decrease the ...
David W. Frederick, Alan V. McDougal, Melisa Semenas, Johanna Vappiani, Andrea Nuzzo, John C. Ulrich, J. David Becherer, Frank Preugschat, Eugene L. Stewart, Daniel C. Sévin, H. Fritz Kramer   +10 more
doaj   +1 more source

Extracellular vesicle distribution and localization in skeletal muscle at rest and following disuse atrophy

Skeletal Muscle, 2023
Background Skeletal muscle (SkM) is a large, secretory organ that produces and releases myokines that can have autocrine, paracrine, and endocrine effects.
Ahmed Ismaeel, Douglas W. Van Pelt, Zachary R. Hettinger, Xu Fu, Christopher I. Richards, Timothy A. Butterfield, Jonathan J. Petrocelli, Ivan J. Vechetti, Amy L. Confides, Micah J. Drummond, Esther E. Dupont-Versteegden   +10 more
doaj   +1 more source

Ca2+‐activated Cl− channels (TMEM16A) underlie spontaneous electrical activity in isolated mouse corpus cavernosum smooth muscle cells

Physiological Reports, 2022
Penile detumescence is maintained by tonic contraction of corpus cavernosum smooth muscle cells (CCSMC), but the underlying mechanisms have not been fully elucidated.
Xin Rui Lim, Bernard T. Drumm, Gerard P. Sergeant, Mark A. Hollywood, Keith D. Thornbury   +4 more
doaj   +1 more source

Mitigating N2O and NO Emissions from Direct-Seeded Rice with Nitrification Inhibitor and Urea Deep Placement

Rice Science, 2020
Soil-emitted nitrous oxide (N2O) and nitric oxide (NO) in crop production are harmful nitrogen (N) emissions that may contribute both directly and indirectly to global warming.
Yam Kanta Gaihre, Upendra Singh, Wendie D. Bible, Job Fugice, Jr., Joaquin Sanabria   +4 more
doaj   +1 more source

Prevalence of multimorbid degenerative lumbar spinal stenosis with knee or hip osteoarthritis: a systematic review and meta-analysis

BMC Musculoskeletal Disorders, 2022
Background Musculoskeletal multimorbidity is common and coexisting lumbar spinal stenosis (LSS) with knee or hip osteoarthritis (OA) has been reported. The aim of this review was to report the prevalence of multimorbid degenerative LSS with knee or hip ...
James J. Young, Rikke Krüger Jensen, Jan Hartvigsen, Ewa M. Roos, Carlo Ammendolia, Carsten Bogh Juhl   +5 more
doaj   +1 more source

Bindarit inhibits human coronary artery smooth muscle cell proliferation, migration and phenotypic switching [PDF]

, 2012
Bindarit, a selective inhibitor of monocyte chemotactic proteins (MCPs) synthesis, reduces neointimal formation in animal models of vascular injury and recently has been shown to inhibit in-stent late loss in a placebo-controlled phase II clinical trial.
Angelo Guglielmotti, Antonio Parisi, Armando Ialenti, Carla Cicala, Daniele De Filippis, Francesco Maione, Gianluca Grassia, Marcella Maddaluno, Maria Vittoria Di Lauro, Nicola Mascolo, Olivier Kocher, Pasquale Maffia, Teresa Iuvone   +12 more
core   +7 more sources

The emergence of Pax7-expressing muscle stem cells during vertebrate head muscle development [PDF]

, 2015
Pax7 expressing muscle stem cells accompany all skeletal muscles in the body and in healthy individuals, efficiently repair muscle after injury. Currently, the in vitro manipulation and culture of these cells is still in its infancy, yet muscle stem ...
Anna eNoble, Colin eSharpe, David J. Goldhamer, Erika C. Jorge, Gabrielle eKardon, Julia eMeireles Nogueira, Julia eMeireles Nogueira, Katarzyna eHawrot, Susanne eDietrich, William M. Wood   +9 more
core   +2 more sources