Results 1 to 10 of about 2,741,127 (298)

Massage increases satellite cell number independent of the age‐associated alterations in sarcolemma permeability

Physiological Reports, 2019
Massage is a widely accepted manual therapy used to modulate the inflammatory response of muscle and restore function, but prolonged compression of muscle potentially causes overt injury and damage to muscle fibers.
Emily R. Hunt, Amy L. Confides, Sarah M. Abshire, Esther E. Dupont‐Versteegden, Timothy A. Butterfield   +4 more
doaj   +1 more source

Mepivacaine reduces calcium transients in isolated murine ventricular cardiomyocytes

BMC Anesthesiology, 2020
Background The potential mechanism of mepivacaine’s myocardial depressant effect observed in papillary muscle has not yet been investigated at cellular level.
Matias Mosqueira, Güçlü Aykut, Rainer H. A. Fink   +2 more
doaj   +1 more source

ANO1 channels are expressed in mouse urethral smooth muscle but do not contribute to agonist or neurally evoked contractions

Scientific Reports
Anoctamin-1 Ca2+-activated Cl− channels (ANO1) are proposed to modulate contractility of urethra smooth muscle cells (USMC), but their cellular expression and contribution to agonist/neural evoked activity is unclear.
Neha Gupta, Salah A. Baker, Kenton M. Sanders, Kaneez E. Rabab, Denzel KF. Thean, Tuleen Alkawadri, Caoimhin S. Griffin, Gerard P. Sergeant, Mark A. Hollywood, Keith D. Thornbury, Bernard T. Drumm   +10 more
doaj   +1 more source

The superoxide dismutase mimetic tempol does not alleviate glucocorticoid‐mediated rarefaction of rat skeletal muscle capillaries

Physiological Reports, 2017
Sustained elevations in circulating glucocorticoids elicit reductions in skeletal muscle microvascular content, but little is known of the underlying mechanisms. We hypothesized that glucocorticoid‐induced oxidative stress contributes to this phenomenon.
Erin R. Mandel, Emily C. Dunford, Ghoncheh Abdifarkosh, Patrick C. Turnbull, Christopher G. R. Perry, Michael C. Riddell, Tara L. Haas   +6 more
doaj   +1 more source

The autophagy inhibitor NSC185058 suppresses mTORC1-mediated protein anabolism in cultured skeletal muscle

Scientific Reports
The mammalian target of rapamycin (mTOR), and specifically the mTOR complex 1 (mTORC1) is the central regulator of anabolism in skeletal muscle. Among the many functions of this kinase complex is the inhibition of the catabolic process of autophagy ...
Patrick J. Ryan, Selina Uranga, Sean T. Stanelle, Megan H. Lewis, Colleen L. O’Reilly, Jessica M. Cardin, J. William Deaver, Aaron B. Morton, James D. Fluckey   +8 more
doaj   +1 more source

Exploring Ultrasonographic Atypical Aspects in Drug‐Resistant Multifocal Chronic Inflammatory Demyelinating Polyneuropathy

Brain and Behavior
Introduction/aims Chronic inflammatory demyelinating polyneuropathy (CIDP) and its variants are characterized by nerve enlargement (NE), particularly in the proximal segments of the median nerve (MN) and cervical roots, as assessed by ultrasound (US). NE
Angela Puma, Aurora Parrotta, Nicolas Azulay, Andra Ezaru, Michele Cavalli, Mihai Ioncea, Luisa Villa, Nicolae Grecu, Giulia Tammam, Sabrina Sacconi, Simona Maccora, Charles Raffaelli   +11 more
doaj   +1 more source

Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice

Scientific Reports
Human hallmarks of sarcopenia include muscle weakness and a blunted response to exercise. Nicotinamide N-methyltransferase inhibitors (NNMTis) increase strength and promote the regenerative capacity of aged muscle, thus offering a promising treatment for
Andrea L. Dimet-Wiley, Christine M. Latham, Camille R. Brightwell, Harshini Neelakantan, Alexander R. Keeble, Nicholas T. Thomas, Haley Noehren, Christopher S. Fry, Stanley J. Watowich   +8 more
doaj   +1 more source

Stuart has got the PoWeR! Skeletal muscle adaptations to a novel heavy progressive weighted wheel running exercise model in C57BL/6 mice

Experimental Physiology
Murine exercise models are developed to study the molecular and cellular mechanisms regulating muscle mass. A progressive weighted wheel running model, named ‘PoWeR’, was previously developed to serve as a more translatable alternative to involuntary ...
Pieter J. Koopmans, Therin D. Williams‐Frey, Kevin A. Zwetsloot   +2 more
doaj   +1 more source

The persistence of changes in insulin sensitivity and metabolic gene expression after acute exercise in male and female mice

Current Research in Physiology
Background: Acute exercise has been suggested to increase insulin sensitivity, although the duration of the improvement may last anywhere from 4 to 72 h.
Jack H. Thompson, Alexa M. Fooskas, Erica J. Locke, Renee N. Washart, Alexandria M. Chin, Paige A.P. Ponzo, Joshua Oduwole, Nicholas DiGiuseppe, Max Matalavage, Stephen C. Kolwicz, Jr.   +9 more
doaj   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio
The complex interplay of metabolic signaling networks is critical to the pathophysiology of lung cancer. The anabolic mTORC1 kinase and catabolic process of autophagy are key among these regulatory pathways.
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
doaj   +1 more source