Results 41 to 50 of about 1,819,951 (268)

Endothelial-specific FoxO1 depletion prevents obesity-related disorders by increasing vascular metabolism and growth

eLife, 2018
Impaired angiogenesis is a hallmark of metabolically dysfunctional adipose tissue in obesity. However, the underlying mechanisms restricting angiogenesis within this context remain ill-defined.
Martina Rudnicki, Ghoncheh Abdifarkosh, Emmanuel Nwadozi, Sofhia V Ramos, Armin Makki, Diane M Sepa-Kishi, Rolando B Ceddia, Christopher GR Perry, Emilie Roudier, Tara L Haas   +9 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Muscle Spindles in Phasic and Tonic Muscle

The Tohoku Journal of Experimental Medicine, 1964
Comparisons were made of muscle spindle structure between phasic and tonic muscles stained by the gold chloride method. The most significant difference was in the ring diameter of the sensory nerve terminals wrapped around the nuclear bags. In tibialis anterior it was largest, in gastrocnemius intermediate, and in soleus smallest.
Honma, Saburo, Seki, Yasuo
openaire   +3 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Multi-omics analysis reveals sex-specific etiology of human muscle weakness following musculoskeletal injury

BMC Medicine
Background Musculoskeletal injuries comprise a growing source of disability worldwide, and the recovery of muscle strength following injury is a critical determinant of patient reported outcomes.
Alexander R. Keeble, Allison M. Owen, Nicholas T. Thomas, Sara Gonzalez-Velez, Camille R. Brightwell, Tyler Barnes, Douglas E. Long, Philip A. Kern, Caitlin E. Conley, Austin V. Stone, Darren L. Johnson, Yuan Wen, Brian Noehren, Christopher S. Fry   +13 more
doaj   +1 more source

Muscle fatigue, bioenergetic responses and metabolic economy during load‐ and velocity‐based maximal dynamic contractions in young and older adults

Physiological Reports, 2023
We evaluated whether task‐dependent, age‐related differences in muscle fatigue (contraction‐induced decline in normalized power) develop from differences in bioenergetics or metabolic economy (ME; mass‐normalized work/mM ATP).
Liam F. Fitzgerald, Miles F. Bartlett, Jane A. Kent   +2 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

An ultrasound and shear wave elastography study: effect of grip on medial elbow joint morphology during valgus stress

BMC Musculoskeletal Disorders
Background The flexor pronator mass (FPM) is an important dynamic stabilizer to valgus stress at the elbow and has been reported to protect against ulnar collateral ligament (UCL) injury.
Matthew F. Gong, Tyler J. Wilps, Jamieson G. Abrams, Shanelle Dorn, Jesal N. Parekh, Tudor H. Hughes, Catherine M. Robertson, Matthew J. Meunier, Samuel R. Ward   +8 more
doaj   +1 more source

Mixing Up Muscle Lengths: The Effects of Training at Different Muscle Lengths in the Elbow Flexors

International Journal of Strength and Conditioning
PURPOSE: This study investigated the effects of resistance training at only longer muscle lengths (LONG) compared to training with a combination of long and short muscle lengths (MIXED).
Seth Hinson, Joshua Pelland, Jacob Remmert, Zac Robinson, Shawn Dinh, Ethan Elkins, Caitlyn Meehand, David Diaz, Brian Benitez, Christian Macarilla, Michael Morgan, Michael Zourdos   +11 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source