HSP70 drives myoblast fusion during C2C12 myogenic differentiation
Biology Open, 2020 In response to injury, skeletal muscle stem cells (MuSCs) undergo myogenesis where they become activated, proliferate rapidly, differentiate and undergo fusion to form multinucleated myotubes. Dramatic changes in cell size, shape, metabolism and motility
Savant S. Thakur +7 more
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Microtubules orchestrate local translation to enable cardiac growth
Nature Communications, 2021 New contractile units are required during cardiac hypertrophy, though it remains unclear precisely where and how these new sarcomeres are added. Here the authors reveal that in the heart, microtubules spatiotemporally regulate mRNAs and ribosomes to ...
Emily A. Scarborough +8 more
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Selective Cricothyroid Muscle Reinnervation by Muscle-Nerve-Muscle Neurotization [PDF]
Archives of Otolaryngology–Head & Neck Surgery, 2001 To determine if selective reinnervation of the cricothyroid muscle could be achieved with muscle-nerve-muscle neurotization.Case series.Tertiary referral center.Three consecutive patients with high vagal lesions that resulted in unilateral laryngeal paralysis.Patients underwent laryngeal reinnervation with ansa hypoglossi to recurrent laryngeal nerve ...
H K, El-Kashlan +5 more
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Accumulation of muscle ankyrin repeat protein transcript reveals local activation of primary myotube endcompartments during muscle morphogenesis [PDF]
, 1997 The characteristic shapes and positions of each individual body muscle are established during the process of muscle morphogenesis in response to patterning information from the surrounding mesenchyme. Throughout muscle morphogenesis, primary myotubes are
Arber, S. +5 more
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Fusion-Independent Satellite Cell Communication to Muscle Fibers During Load-Induced Hypertrophy
Function, 2020 The “canonical” function of Pax7+ muscle stem cells (satellite cells) during hypertrophic growth of adult muscle fibers is myonuclear donation via fusion to support increased transcriptional output.
Kevin A Murach +11 more
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Skeletal Muscle, 2022 Background Aging decreases skeletal muscle mass and quality. Maintenance of healthy muscle is regulated by a balance between protein and organellar synthesis and their degradation.
Matthew Triolo +3 more
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External physical and biochemical stimulation to enhance skeletal muscle bioengineering [PDF]
, 2015 Cell based muscle tissue engineering carries the potential to revert the functional loss of muscle tissue caused by disease and trauma. Although muscle tissue can be bioengineered using various precursor cells, major limitations still remain.; In the ...
Handschin, Christoph +5 more
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Scientific Reports, 2019 Duchenne muscular dystrophy (DMD) is an X-linked genetic disease characterized by progressive muscle wasting and weakness and premature death. Glucocorticoids (e.g.
Daniel J. Ham +9 more
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Trends in concentrations of atmospheric gaseous and particulate species in rural eastern Tennessee as related to primary emission reductions [PDF]
Atmospheric Chemistry and Physics, 2015 Air quality measurements at Look Rock, Tennessee – on the western edge of the Great Smoky Mountains National Park – were begun in 1980 and expanded during the 1980s to a National Park Service (NPS) IMPROVE network station.
R. L. Tanner +2 more
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Molecular brakes regulating mTORC1 activation in skeletal muscle following synergist ablation [PDF]
, 2014 The goal of the current work was to profile positive (mTORC1 activation, autocrine/paracrine growth factors) and negative [AMPK, unfolded protein response (UPR)] pathways that might regulate overload-induced mTORC1 activation with the hypothesis that a ...
Hamilton, D. Lee +20 more
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